Immune System Modeling and Simulations

This book describes a computational model of the immune system reaction, C-ImmSim. The book presents the basic model as well as the various customizations to implement the description of different diseases and the way they have been used to produce new knowledge either from hypothesis or from experimental data. The book can be used as a practical guide to implement a computational model with which to study a specific disease and to try to address realistic clinical questions.

On the model inconsistencies in simulating breaking wave with mesh-based and particle methods

In the present work the numerical simulation of breaking wave processes is discussed. A detailed analysis is performed using Smoothing Particle Hydrodynamics (SPH) models as well as a mesh-based Level-Set Finite Volume Method (LS-FVM). Considerations on the numerical dissipation involved in such models are discussed within the frameworks of weakly compressible and incompressible ssumptions. The breaking wave processes are simulated using both mono- and two-phases models. Due to the extensive test-cases discussed, the present analysis is limited to a bi-dimensional framework.

CFD analysis of propeller-rudder interaction

Interaction of the vortex systems detached from a propeller with a rudder installed in its wake is investigated by CFD. The correct prediction of this phenomenon is of great interest in naval hydrodynamics research, it being the source of irradiated noise and vibratory loads. The phenomenology is addressed by simulating a single bladed propeller (INSEAN E779A) and a rudder characterized by a rectangular plane area and symmetric sectional shape (NACA0020 profiles).

Orbital effects due to gravitational induction

We study the motion of test particles in the metric of a localized and slowly rotating astronomical source, within the framework of linear gravitoelectromagnetism, grounded on a Post-Minkowskian approximation of general relativity. Special attention is paid to gravitational inductive effects due to time-varying gravitomagnetic fields. We show that, within the limits of the approximation mentioned above, there are cumulative effects on the orbit of the particles either for planetary sources or for binary systems. They turn out to be negligible.

Dynamics of extended bodies in a Kerr spacetime with spin-induced quadrupole tensor

The features of equatorial motion of an extended body in Kerr spacetime are investigated in the framework of the Mathisson-Papapetrou-Dixon model. The body is assumed to stay at quasiequilibrium and respond instantly to external perturbations. Besides the mass, it is completely determined by its spin, the multipolar expansion being truncated at the quadrupole order, with a spin-induced quadrupole tensor. The study of the radial effective potential allows us to analytically determine the innermost stable circular orbit shift due to spin and the associated frequency of the last circular orbit.

Chronology protection in the Kerr metric

We show that causality violation in a Kerr naked singularity spacetime is constrained by the existence of (radial) potential barriers. We extend to the class of vortical non-equatorial null geodesics confined to $$\theta $$? $$=$$= constant hyperboloids (boreal orbits) previous results concerning timelike ones (Calvani et al. in Gen Rel Gravit 9:155, 1978), showing that within this class of orbits, the causality principle is rigorously satisfied.

Numerical simulations of aggregate breakup in bounded and unbounded turbulent flows

Breakup of small aggregates in fully developed turbulence is studied by means of direct numerical simulations in a series of typical bounded and unbounded flow configurations, such as a turbulent channel flow, a developing boundary layer and homogeneous isotropic turbulence. The simplest criterion for breakup is adopted, whereby aggregate breakup occurs when the local hydrodynamic stress "1=2, with " being the energy dissipation at the position of the aggregate, overcomes a given threshold cr, which is characteristic for a given type of aggregate.

Muscl reconstruction and haar wavelets

MUSCL extensions (Monotone Upstream-centered Schemes for Conservation Laws) of the Godunov numerical scheme for scalar conservation laws are shown to admit a rather simple reformulation when recast in the formalism of the Haar multi-resolution analysis of L<sup>2</sup>(R). By pursuing this wavelet reformulation, a seemingly new MUSCL-WB scheme is derived for advection-reaction equations which is stable for a Courant number up to 1 (instead of roughly 1/2 ).

Combining pathway identification and survival prediction via screening-network analysis

Motivation Gene expression data from high-throughput assays, such as microarray, are often used to predict cancer survival. However, available datasets consist of a small number of samples (n patients) and a large number of gene expression data (p predictors). Therefore, the main challenge is to cope with the high-dimensionality, i.e. p>>n, and a novel appealing approach is to use screening procedures to reduce the size of the feature space to a moderate scale (Wu & Yin 2015, Song et al. 2014, He et al. 2013).