In this paper we present a general model of drug release from a drug delivery device and the subsequent transport in biological tissue. The model incorporates drug diffusion, dissolution and solubility in the polymer coating, coupled with diffusion, convection and reaction in the biological tissue. Each layer contains bound and free drug phases so that the resulting model is a coupled two-phase two-layer system of partial differential equations. One of the novelties is the generality of the model in each layer.

We obtain a comparison result for solutions to nonlinear fully anisotropic elliptic problems by means of anisotropic symmetrization. As consequence we deduce a priori estimates for norms of the relevant solutions.

We present the open-source computer program JETSPIN, specifically designed to simulate the electro-spinning process of nanofibers. Its capabilities are shown with proper reference to the underlying model, as well as a description of the relevant input variables and associated test-case simulations. The various interactions included in the electrospinning model implemented in JETSPIN are discussed in detail. The code is designed to exploit different computational architectures, from single to parallel processor workstations.

We present a nonlinear Langevin model to investigate the early-stage dynamics of electrified polymer jets in electrospinning experiments. In particular, we study the effects of air drag force on the uniaxial elongation of the charged jet, right after ejection from the nozzle. Numerical simulations show that the elongation of the jet filament close to the injection point is significantly affected by the nonlinear drag exerted by the surrounding air. These results provide useful insights for the optimal design of current and future electrospinning experiments.

We investigate the effects of dissipative air drag on the dynamics of electrified jets in the initial stage of the electrospinning process. The main idea is to use a Brownian noise to model air drag effects on the uniaxial elongation of the jets. The developed numerical model is used to probe the dynamics of electrified polymer jets at different conditions of air drag force, showing that the dynamics of the charged jet is strongly biased by the presence of air drag forces. This study provides prospective beneficial implications for improving forthcoming electrospinning experiments.

We establish a comparison result for solutions to nonlinear fully anisotropic elliptic problems by means of anisotropic symmetrization. As consequence we deduce a priori estimates for norms of the relevant solutions.

In the present work the numerical simulation of breaking wave processes is discussed. A detailed analysis is performed using Smoothing Particle Hydrodynamics (SPH) models as well as a mesh-based Level-Set Finite Volume Method (LS-FVM). Considerations on the numerical dissipation involved in such models are discussed within the frameworks of weakly compressible and incompressible ssumptions. The breaking wave processes are simulated using both mono- and two-phases models. Due to the extensive test-cases discussed, the present analysis is limited to a bi-dimensional framework.