Information content of long-range NMR data for the characterization of conformational heterogeneity
Long-range NMR data, namely residual dipolar
couplings (RDCs) from external alignment and paramagnetic
data, are becoming increasingly popular for the
characterization of conformational heterogeneity of multidomain
biomacromolecules and protein complexes. The
question addressed here is how much information is contained
in these averaged data.






