We consider a class of integral equations of Volterra type with constant coefficients containing a logarithmic difference kernel. This class coincides for a=0 with the Symm's euqtion. We can transform the general integral equation into an equivalent singular equation of Cauchy type which allows us to give the explicit formula for the solution. The numerical method proposed in this paper consists in substituting this in the experrsion of the solution g.

We present a multiphase mathematical model for tumor growth which incorporates the remodeling of the extracellular matrix and describes the formation of fibrotic tissue by tumor cells. We also detail a full qualitative analysis of the spatially homogeneous problem, and study the equilibria of the system in order to characterize the conditions under which fibrosis may occur. © 2010 Elsevier Ltd.

While drawing a link between the papers contained in this issue and those present in a previous one (Vol. 2, Issue 3), this introductory article aims at putting in evidence some trends and challenges on cancer modelling, especially related to the development of multiphase and multiscale models. © EDP Sciences, 2009.

This paper deals with models of living complex systems, chiefly human crowds, by methods of conservation laws and measure theory. We introduce a modeling framework which enables one to address both discrete and continuous dynamical systems in a unified manner using common phenomenological ideas and mathematical tools as well as to couple these two descriptions in a multiscale perspective. Furthermore, we present a basic theory of well-posedness and numerical approximation of initial-value problems and we discuss its implications on mathematical modeling.

Resorting to a multiphase modelling framework, tumours are described here as a mixture of tumour and host cells within a porous structure constituted by a remodelling extracellular matrix (ECM), which is wet by a physiological extracellular fluid. The model presented in this article focuses mainly on the description of mechanical interactions of the growing tumour with the host tissue, their influence on tumour growth, and the attachment/detachment mechanisms between cells and ECM.

We consider a class of integral equations of Volterra type with constant coefficients containing a logarithmic difference kernel. This class coincides for a=0 with the Symm's equation. We can transform the general integral equation into an equivalent singular equation of Cauchy type which allows us to give an explicit formula for the solution g. The numerical method proposed in this paper consists in substituting the Lagrange polynomial interpolating the known function f in the expression of the solution g.