Acute myeloid leukemia (AML) arises from a complex sequence of biological and finely orchestrated events that are still poorly understood. Increasingly, epigenetic studies are providing exciting findings that may be exploited in promising and personalized cutting-edge therapies. A more appropriate and broader screening of possible players in cancer could identify a master molecular mechanism in AML. Here, we build on our previously published study by evaluating a histone deacetylase (HDAC)2-mediated miRNA regulatory network in U937 leukemic cells.

The societal impact of traffic is a long-standing and complex problem. We focus on the estimation of ground-level ozone production due to vehicular traffic. We propose a comprehensive computational approach combining four consecutive modules: a traffic simulation module, an emission module, a module for the main chemical reactions leading to ozone production, and a module for the diffusion of gases in the atmosphere. The traffic module is based on a second-order traffic flow model, obtained by choosing a special velocity function for the Collapsed Generalized Aw-Rascle-Zhang model.

Magnetoencephalography (MEG) aims at reconstructing the unknown neuroelectric activity in the brain from non-invasive measurements of the magnetic field induced by neural sources. The solution of this ill-posed, ill-conditioned inverse problem is usually dealt with using regularization techniques that are often time-consuming, and computationally and memory storage demanding. In this paper we analyze how a slimmer procedure, random sampling, affects the estimation of the brain activity generated by both synthetic and real sources.

The MagnetoEncephaloGraphy (MEG) has gained great interest in neurorehabilitation training due to its high temporal resolution. The challenge is to localize the active regions of the brain in a fast and accurate way. In this paper we use an inversion method based on random spatial sampling to solve the real-time MEG inverse problem. Several numerical tests on synthetic but realistic data show that the method takes just a few hundredths of a second on a laptop to produce an accurate map of the electric activity inside the brain. Moreover, it requires very little memory storage.

We develop and study stability properties of a hybrid approximation of functionals of the Bates jump model with stochastic interest rate that uses a tree method in the direction of the volatility and the interest rate and a finite-difference approach in order to handle the underlying asset price process. We also propose hybrid simulations for the model, following a binomial tree in the direction of both the volatility and the interest rate, and a space-continuous approximation for the underlying asset price process coming from a Euler-Maruyama type scheme.

We present the first analytical computation of the (conservative) gravitational self-force correction to the periastron advance around a spinning black hole. Our result is accurate to the second order in the rotational parameter and through the 9.5 post-Newtonian level. It has been obtained as the circular limit of the correction to the gyroscope precession invariant along slightly eccentric equatorial orbits in the Kerr spacetime. The latter result is also new and we anticipate here the first few terms only of the corresponding post-Newtonian expansion.

In Rayleigh-Bénard convection (RBC) for fluids with Prandtl number Pr1, rotation beyond a critical (small) rotation rate is known to cause a sudden enhancement of heat transfer, which can be explained by a change in the character of the boundary layer (BL) dynamics near the top and bottom plates of the convection cell. Namely, with increasing rotation rate, the BL signature suddenly changes from Prandtl-Blasius type to Ekman type.

Recent numerical analyses to optimize the design of microfluidic devices for more effective entrapment or segregation of surrogate circulating tumor cells (CTCs) from healthy cells have been reported in the literature without concurrently accommodating the non-Newtonian nature of the body fluid and the non-uniform geometric shapes of the CTCs.

The dynamics of inertial particles in Rayleigh-Benard convection, where both particles and fluid exhibit thermal expansion, is studied using direct numerical simulations (DNS) in the soft-turbulence regime. We consider the effect of particles with a thermal expansion coefficient larger than that of the fluid, causing particles to become lighter than the fluid near the hot bottom plate and heavier than the fluid near the cold top plate.