Hypomorphic mutations in DNA-methyltransferase DNMT3B cause majority of the rare disorder Immunodeficiency, Centromere instability and Facial anomalies syndrome cases (ICF1). By unspecified mechanisms, mutant-DNMT3B interferes with lymphoid-specific pathways resulting in immune response defects. Interestingly, recent findings report that DNMT3B shapes intragenic CpG-methylation of highly-transcribed genes. However, how the DNMT3B-dependent epigenetic network modulates transcription and whether ICF1-specific mutations impair this process remains unknown.

Significant improvements in the computational performance of the lattice-Boltzmann (LB) model, coded in FORTRAN90, were achieved through application of enhancement techniques. Applied techniques include optimization of array memory layouts, data structure simplification, random number generation outside the simulation thread(s), code parallelization via OpenMP, and intra- and inter-timestep task pipelining.

Active research in nanotechnology contemplates the use of nanomaterials for environmental engineering applications. However, a primary challenge is understanding the effects of nanomaterial properties on industrial device performance and translating unique nanoscale properties to the macroscale. One emerging example consists of graphene oxide (GO) membranes for separation processes. Thus, here we investigate how individual GO properties can impact GO membrane characteristics and water permeability.

We obtain a comparison result for solutions to nonlinear fully anisotropic elliptic problems by means of anisotropic symmetrization. As consequence we deduce a priori estimates for norms of the relevant solutions.

One of the most distinctive hallmarks of many-body systems far from equilibrium is the spontaneous emergence of order under conditions where disorder would be plausibly expected. Here, we report on the self-transition between ordered and disordered emulsions in divergent microfluidic channels, i.e., from monodisperse assemblies to heterogeneous polydisperse foamlike structures, and back again to ordered ones.

Cyber insurance is a rapidly developing area which draws more and more attention of practitioners and researchers. Insurance, an alternative way to deal with residual risks, was only recently applied to the cyber world. The immature cyber insurance market faces a number of unique challenges on the way of its development.In this paper we summarise the basic knowledge about cyber insurance available so far from both market and scientific perspectives. We provide a common background explaining basic terms and formalisation of the area.

The Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) measured the middle-infrared limb emission spectrum of the atmosphere from 2002 to 2012 on board ENVISAT, a polar-orbiting satellite. Recently, the European Space Agency (ESA) completed the final reprocessing of MIPAS measurements, using version 8 of the level 1 and level 2 processors, which include more accurate models, processing strategies, and auxiliary data. The list of retrieved gases has been extended, and it now includes a number of new species with weak emission features in the MIPAS spectral range.

Thermal and mechanical energy storage is pivotal for the effective exploitation of renewable energy sources, thus fostering the transition to a sustainable economy. Hydrogen-based systems are among the most promising solutions for electrical energy storage. However, several technical and economic barriers (e.g., high costs, low energy and power density, advanced material requirements) still hinder the diffusion of such solutions.

In this paper we propose and study a hybrid discrete-continuous mathematical model of collective motion under alignment and chemotaxis effect. Starting from paper [23], in which the Cucker-Smale model [22] was coupled with other cell mechanisms, to describe the cell migration and self-organization in the zebrafish lateral line primordium, we introduce a simplified model in which the coupling between an alignment and chemotaxis mechanism acts on a system of interacting particles.