Insight Onto the Utility of Magnetoencephalography and Electroencephalography for Studying Brain Disorders

MagnetoEncephaloGraphy (MEG) and ElectroEncephaloGraphy (EEG) are the most common non-invasive brain imaging techniques for monitoring the electrical brain activity with millisecond resolution. Due to their high, millisecond, temporal resolution, these techniques are also the most suitable for studying the dynamic interplay of between brain regions during information processing. In clinical settings, MEG and EEG are valuable methods for the pre-surgical evaluation of patients with pharmaco-resistant epilepsy.

Distinct Antigen Delivery Systems Induce Dendritic Cells' Divergent Transcriptional Response: New Insights from a Comparative and Reproducible Computational Analysis.

Vaccination is the most successful and cost-effective method to prevent infectious diseases. However, many vaccine antigens have poor in vivo immunogenic potential and need adjuvants to enhance immune response. The application of systems biology to immunity and vaccinology has yielded crucial insights about how vaccines and adjuvants work. We have previously characterized two safe and powerful delivery systems derived from non-pathogenic prokaryotic organisms: E2 and fd filamentous bacteriophage systems.

Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL

Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2 5-phosphatase. Here we unveil a lysosomal response to the arrival of autophagosomal cargo in which OCRL plays a key part. We identify mitochondrial DNA and TLR9 as the cargo and the receptor that triggers and mediates, respectively, this response.

Local membrane length conservation in two-dimensional vesicle simulation using a multicomponent lattice Boltzmann equation method

We present a method for applying a class of velocity-dependent forces within a multicomponent lattice Boltzmann equation simulation that is designed to recover continuum regime incompressible hydrodynamics. This method is applied to the problem, in two dimensions, of constraining to uniformity the tangential velocity of a vesicle membrane implemented within a recent multicomponent lattice Boltzmann simulation method, which avoids the use of Lagrangian boundary tracers.

Altered brain criticality in Schizophrenia: New insights from MEG

Schizophrenia has a complex etiology and symptomatology that is difficult to untangle. After decades of research, important advancements towards a central biomarker are still lacking. One of the missing pieces is a better understanding of how non-linear neural dynamics are altered in this patient population. In this study, the resting-state neuromagnetic signals of schizophrenia patients and healthy controls were analyzed in the framework of criticality.

NUMERICAL ANALYSIS OF ASYMPTOTICALLY CONVOLUTION EVOLUTIONARY INTEGRAL EQUATIONS

Asymptotically convolution Volterra equations are characterized by kernel functions which exponentially decay to convolution ones. Their importance in the applications motivates a numerical analysis of the asymptotic behavior of the solution. Here the quasi-convolution nature of the kernel is exploited in order to investigate the stability of .; / methods for general systems and in some particular cases.