Neural oscillations track natural but not artificial fast speech: Novel insights from speech-brain coupling using MEG

Neural oscillations contribute to speech parsing via cortical tracking of hierarchical linguistic structures, including syllable rate. While the properties of neural entrainment have been largely probed with speech stimuli at either normal or artificially accelerated rates, the important case of natural fast speech has been largely overlooked. Using magnetoencephalography, we found that listening to naturally-produced speech was associated with cortico-acoustic coupling, both at normal (~6 syllables/s) and fast (~9 syllables/s) rates, with a corresponding shift in peak entrainment frequency.

Smoothed particle hydrodynamics method from a large eddy simulation perspective

The Smoothed Particle Hydrodynamics (SPH) method, often used for the modelling of the Navier- Stokes equations by a meshless Lagrangian approach, is revisited from the point of view of Large Eddy Simulation (LES). To this aim, the LES filtering procedure is recast in a Lagrangian framework by defining a filter that moves with the positions of the fluid particles at the filtered velocity.

Loss-of-function variants in exon 4 of TAB2 cause a recognizable multisystem disorder with cardiovascular, facial, cutaneous, and musculoskeletal involvement

Purpose: This study aimed to describe a multisystemic disorder featuring cardiovascular, facial, musculoskeletal, and cutaneous anomalies caused by heterozygous loss-of-function variants in TAB2. Methods: Affected individuals were analyzed by next-generation technologies and genomic array. The presumed loss-of-function effect of identified variants was assessed by luciferase assay in cells transiently expressing TAB2 deleterious alleles. In available patients' fibroblasts, variant pathogenicity was further explored by immunoblot and osteoblast differentiation assays.

On the regularity of solutions to a class of degenerate PDE's with lower order terms

In this paper we establish the boundedness and the higher differentiability of solutions to the {div(A(x,Du))+b(x)|u(x)|u(x)=fin ?u=0on ?? under a Sobolev assumption on the partial map x->A(x,?). The novelty here is that we deal with degenerate elliptic operator A(x,?) with p-growth, p>=2, with respect to the gradient variable, in presence of lower order terms. The interplay between b(x) and f(x), introduced in ([1]), gives a regularizing effect also in the degenerate elliptic setting.

The impact of MEG source reconstruction method on source-space connectivity estimation: A comparison between minimum-norm solution and beamforming

Despite numerous important contributions, the investigation of brain connectivity with magnetoencephalography (MEG) still faces multiple challenges. One critical aspect of source-level connectivity, largely overlooked in the literature, is the putative effect of the choice of the inverse method on the subsequent cortico-cortical coupling analysis. We set out to investigate the impact of three inverse methods on source coherence detection using simulated MEG data. To this end, thousands of randomly located pairs of sources were created.

Single-Cell RNA Sequencing Analysis: A Step-by-Step Overview

Thanks to innovative sample-preparation and sequencing technologies, gene expression in individual cells can now be measured for thousands of cells in a single experiment. Since its introduction, single-cell RNA sequencing (scRNA-seq) approaches have revolutionized the genomics field as they created unprecedented opportunities for resolving cell heterogeneity by exploring gene expression profiles at a single-cell resolution. However, the rapidly evolving field of scRNA-seq invoked the emergence of various analytics approaches aimed to maximize the full potential of this novel strategy.

Low energy configurations of topological singularities in two dimensions: A Gamma-convergence analysis of dipoles

This paper deals with the variational analysis of topological singularities in two dimensions. We consider two canonical zero-temperature models: the core radius approach and the Ginzburg-Landau energy. Denoting by epsilon the length scale parameter in such models, we focus on the vertical bar log epsilon VERBAR; energy regime.