Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients

A prodromal phase of Parkinson's disease (PD) may precede motor manifestations by decades. PD patients' siblings are at higher risk for PD, but the prevalence and distribution of prodromal symptoms are unknown. The study objectives were (1) to assess motor and non-motor features estimating prodromal PD probability in PD siblings recruited within the European PROPAG-AGEING project; (2) to compare motor and non-motor symptoms to the well-established DeNoPa cohort.

Discrete fluidization of dense monodisperse emulsions in neutral wetting microchannels

The rheology of pressure-driven flows of two-dimensional dense monodisperse emulsions in neutral wetting microchannels is investigated by means of mesoscopic lattice Boltzmann simulations, capable of handling large collections of droplets, in the order of several hundreds. The simulations reveal that the fluidization of the emulsion proceeds through a sequence of discrete steps, characterized by yielding events whereby layers of droplets start rolling over each other, thus leading to sudden drops of the relative effective viscosity.

Identification and validation of viral antigens sharing sequence and structural homology with tumor-associated antigens (TAAs)

Background The host's immune system develops in equilibrium with both cellular self-antigens and non-self-antigens derived from microorganisms which enter the body during lifetime. In addition, during the years, a tumor may arise presenting to the immune system an additional pool of non-self-antigens, namely tumor antigens (tumor-associated antigens, TAAs; tumor-specific antigens, TSAs). Methods In the present study, we looked for homology between published TAAs and non-self-viral-derived epitopes. Bioinformatics analyses and ex vivo immunological validations have been performed.

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex

ZBTB2 is a protein belonging to the BTB/POZ zinc-finger family whose members typically contain a BTB/POZ domain at the N-terminus and several zinc-finger domains at the C-terminus. Studies have been carried out to disclose the role of ZBTB2 in cell proliferation, in human cancers and in regulating DNA methylation. Moreover, ZBTB2 has been also described as an ARF, p53 and p21 gene repressor as well as an activator of genes modulating pluripotency. In this scenario, ZBTB2 seems to play many functions likely associated with other proteins.

A non-standard numerical scheme for an age-of-infection epidemic model

We propose a numerical method for approximating integro-differential equations arising in age-of-infection epidemic models. The method is based on a non-standard finite differences approximation of the integral term appearing in the equation. The study of convergence properties and the analysis of the qualitative behavior of the numerical solution show that it preserves all the basic properties of the continuous model with no restrictive conditions on the step-length h of integration and that it recovers the continuous dynamic as h tends to zero.

Higher-order tail contributions to the energy and angular momentum fluxes in a two-body scattering process

The need for more and more accurate gravitational-wave templates requires taking into account all possible contributions to the emission of gravitational radiation from a binary system. Therefore, working within a multipolar-post-Minkowskian framework to describe the gravitational-wave field in terms of the source multipole moments, the dominant instantaneous effects should be supplemented by hereditary contributions arising from nonlinear interactions between the multipoles.

An Integration by Parts Formula for Functionals of the Dirichlet-Ferguson Measure, and Applications

The Dirichlet-Ferguson measure is a random probability measure that has seen widespread use in Bayesian nonparametrics. Our main results can be seen as a first step towards the development of a stochastic analysis of the Dirichlet-Ferguson measure. We define a gradient that acts on functionals of the measure and derive its adjoint. The corresponding integration by parts formula is used to prove a covariance representation formula for square integrable functionals of the Dirichlet-Ferguson measure and to provide a quantitative central limit theorem for the first chaos.

A nonlinear parabolic model arising in marble sulphation: qualitative analysis

We present a simple model describing the chemical aggression undergone by calcium carbonate rocks in presence of acid atmosphere. A large literature is available on the deterioration processes of building stones, in particular in connection with problems concerning historical buildings in the field of Cultural Heritage. It is well known that the greatest aggression is caused by SO2 andNO3. In this paper we consider the corrosion caused by sulphur dioxide, which, reacting with calcium carbonate, produces gypsum.