Diffusive limits of 2D well-balanced schemes for kinetic models of neutron transport

Two-dimensional dissipative and isotropic kinetic models, like the ones used in neutron transport theory, are considered. Especially, steady-states are expressed for constant opacity and damping, allowing to derive a scattering S-matrix and corresponding "truly 2D well-balanced" numerical schemes. A first scheme is obtained by directly implementing truncated Fourier-Bessel series, whereas another proceeds by applying an exponential modulation to a former, conservative, one. Consistency with the asymptotic damped parabolic approximation is checked for both algorithms.

Emulating complex simulations by machine learning methods

Background: The aim of the present paper is to construct an emulator of a complex biological system simulator using a machine learning approach. More specifically, the simulator is a patient-specific model that integrates metabolic, nutritional, and lifestyle data to predict the metabolic and inflammatory processes underlying the development of type-2 diabetes in absence of familiarity. Given the very high incidence of type-2 diabetes, the implementation of this predictive model on mobile devices could provide a useful instrument to assess the risk of the disease for aware individuals.

Parameter estimation for cardiovascular flow modeling of fetal circulation

The present paper represents a first methodological work for the construction of a robust and accurate algorithm for the solution of an inverse problem given by the identification of the parameters of a lumped mathematical model of fetal circulation introduced by G. Pennati et al. (1997). The underlying estimation techniques here applied are two global search meth- ods, respectively a Parameter Space Investigation (PSI) and the Ensemble Kalman Filter (EnKF), with a refinement performed with a local search method, i.e. Levenberg- Marquardt method (LM).

Biomimetic Nanotherapies: Red Blood Cell Based Core-Shell Structured Nanocomplexes for Atherosclerosis Management

Cardiovascular disease is the leading cause of mortality worldwide. Atherosclerosis, one of the most common forms of the disease, is characterized by a gradual formation of atherosclerotic plaque, hardening, and narrowing of the arteries. Nanomaterials can serve as powerful delivery platforms for atherosclerosis treatment. However, their therapeutic efficacy is substantially limited in vivo due to nonspecific clearance by the mononuclear phagocytic system.

ROBustness In Network (robin): an R Package for Comparison and Validation of Communities

In network analysis, many community detection algorithms have been developed. However, their implementation leaves unaddressed the question of the statistical validation of the results. Here, we present robin (ROBustness In Network), an R package to assess the robustness of the community structure of a network found by one or more methods to give indications about their reliability.

Automatic coarsening in Algebraic Multigrid utilizing quality measures for matching-based aggregations Pasqua D'Ambra, Fabio Durastante, Salvatore Filippone, Ludmil Zikatanov

In this paper, we discuss the convergence of an Algebraic MultiGrid (AMG) method for general symmetric positive-definite matrices. The method relies on an aggregation algorithm, named coarsening based on compatible weighted matching, which exploits the interplay between the principle of compatible relaxation and the maximum product matching in undirected weighted graphs.

Investigating new forms of gravity-matter couplings in the gravitational field equations

This paper proposes a toy model where, in the Einstein equations, the right-hand side is modified by the addition of a term proportional to the symmetrized partial contraction of the Ricci tensor with the energy-momentum tensor, while the left-hand side remains equal to the Einstein tensor. Bearing in mind the existence of a natural length scale given by the Planck length, dimensional analysis shows that such a term yields a correction linear in ? to the classical term that is instead just proportional to the energy-momentum tensor.

Fractional Orlicz-Sobolev spaces

The optimal Orlicz target space and the optimal rearrangement-invariant tar- get space are exhibited for embeddings of fractional-order Orlicz-Sobolev spaces W^{s,A}(R^n). Related Hardy type inequalities are proposed as well. Versions for frac- tional Orlicz-Sobolev seminorms of the Bourgain-Brezis-Mironescu theorem on the limit as s->1^- and of the Maz'ya-Shaposhnikova theorem on the limit as s ->0^+ are established. This is a joint work with Andrea Cianchi, Lubos Pick and Lenka Slavikova.

Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm.

The poles of the heart and branchiomeric muscles of the face and neck are formed from the cardiopharyngeal mesoderm within the pharyngeal apparatus. They are disrupted in patients with 22q11.2 deletion syndrome, due to haploinsufficiency of TBX1, encoding a T-box transcription factor. Here, using single cell RNA-sequencing, we now identify a multilineage primed population within the cardiopharyngeal mesoderm, marked by Tbx1, which has bipotent properties to form cardiac and branchiomeric muscle cells.

The vortex-driven dynamics of droplets within droplets

Understanding the fluid-structure interaction is crucial for an optimal design and manufacturing of soft mesoscale materials. Multi-core emulsions are a class of soft fluids assembled from cluster configurations of deformable oil-water double droplets (cores), often employed as building-blocks for the realisation of devices of interest in bio-technology, such as drug-delivery, tissue engineering and regenerative medicine.