Gravitational scattering at the seventh order in G: Nonlocal contribution at the sixth post-Newtonian accuracy

A recently introduced approach to the classical gravitational dynamics of binary systems involves intricate integrals (linked to a combination of nonlocal-in-time interactions with iterated 1r-potential scattering) which have so far resisted attempts at their analytical evaluation.

Network Clustering by Embedding of Attribute-augmented Graphs

In this paper we propose a new approach to detect clusters in undirected graphs with attributed vertices. The aim is to group vertices which are similar not only in terms of structural connectivity but also in terms of attribute values. We incorporate structural and attribute similarities between the vertices in an augmented graph by creating additional vertices and edges as proposed in [6, 38]. The augmented graph is then embedded in a Euclidean space associated to its Laplacian where a modified K-means algorithm is applied to identify clusters.

Mesoscale modelling of droplets' self-assembly in microfluidic channels

A recently proposed mesoscale approach for the simulation of multicomponent flows with near-contact interactions is employed to investigate the early stage formation and clustering statistics of soft flowing crystals in microfluidic channels. Specifically, we first demonstrate the ability of the aforementioned mesoscale model to accurately reproduce main mechanisms leading to the formation of two basic droplet patterns (triangular and hexagonal), in close agreement with experimental evidence.

Modeling the Effect of High Calorie Diet on the Interplay between Adipose Tissue, Inflammation, and Diabetes

Background. Type 2 diabetes (T2D) is a chronic metabolic disease potentially leading to serious widespread tissue damage. Human organism develops T2D when the glucose-insulin control is broken for reasons that are not fully understood but have been demonstrated to be linked to the emergence of a chronic inflammation. Indeed such low-level chronic inflammation affects the pancreatic production of insulin and triggers the development of insulin resistance, eventually leading to an impaired control of the blood glucose concentration.

Fractional Orlicz-Sobolev spaces and their limits

We establish versions for fractional Orlicz-Sobolev seminorms, built upon Young functions, of the Bourgain-Brezis-Mironescu theorem on the limit as s ->1^-, and of the Maz'ya-Shaposhnikova theorem on the limit as s->0^-, dealing with classical fractional Sobolev spaces. As regards the limit as s ->1^-, Young functions with an asymptotic linear growth are also considered in connection with the space of functions of bounded variation. Concerning the limit as s->0^+, Young functions fulfilling the \Delta_2-condition are admissible.

Sixth post-Newtonian local-in-time dynamics of binary systems

Using a recently introduced method [D. Bini, T. Damour, and A. Geralico, Phys. Rev. Lett. 123, 231104 (2019)], which splits the conservative dynamics of gravitationally interacting binary systems into a nonlocal-in-time part and a local-in-time one, we compute the local part of the dynamics at the sixth post-Newtonian (6PN) accuracy. Our strategy combines several theoretical formalisms: post-Newtonian, post-Minkowskian, multipolar-post-Minkowskian, effective-field-theory, gravitational self-force, effective one-body, and Delaunay averaging.

Three-stage multiscale modelling of the NMDA neuroreceptor

We present a new multistage method to study the N-Methyl-D-Aspartate (NMDA) neuroreceptor starting from the reconstruction of its crystallographic structure. Thanks to the combination of Homology Modelling, Molecular Dynamics and Lattice Boltzmann simulations, we analyse the allosteric transition of NDMA upon ligand binding and compute the receptor response to ionic passage across the membrane.

Analisys of a nonlinear model arising in chemical aggression of marble

We present a simple model describing the chemical aggression undergone by calcium carbonate rocks in presence of acid atmosphere. A large literature is available on the deterioration processes of building stones, in particular in connection with problems concerning historical buildings in the field of Cultural Heritage. It is well known that the greatest aggression is caused by sulfur dioxide and nitrate. In this paper we consider the corrosion caused by sulphur dioxide, which, reacting with calcium carbonate, produces gypsum.

Radiative contributions to gravitational scattering

The linear-order effects of radiation-reaction on the classical scattering of two point masses, in general relativity, are derived by a variation-of-constants method. Explicit expressions for the radiation-reaction contributions to the changes of 4-momentum during scattering are given to linear order in the radiative losses of energy, linear-momentum, and angular momentum. The polynomial dependence on the masses of the 4-momentum changes is shown to lead to nontrivial identities relating the various radiative losses.

Estimation algorithm for a hybrid pde-ode model inspired by immunocompetent cancer-on-chip experiment

The present work is motivated by the development of a mathematical model mimicking the mechanisms observed in lab-on-chip experiments, made to reproduce on microfluidic chips the in vivo reality. Here we consider the Cancer-on-Chip experiment where tumor cells are treated with chemotherapy drug and secrete chemical signals in the environment attracting multiple immune cell species. The in silico model here proposed goes towards the construction of a "digital twin" of the experimental immune cells in the chip environment to better understand the complex mechanisms of immunosurveillance.