Background: The aim of a recent research project was the investigation of the mechanisms involved in the onset of type 2 diabetes in the absence of familiarity. This has led to the development of a computational model that recapitulates the aetiology of the disease and simulates the immunological and metabolic alterations linked to type-2 diabetes subjected to clinical, physiological, and behavioural features of prototypical human individuals. Results: We analysed the time course of 46,170 virtual subjects, experiencing different lifestyle conditions.

In this paper, the asymptotic behaviour of the numerical solution to the Volterra integral equations is studied. In particular, a technique based on an appropriate splitting of the kernel is introduced, which allows one to obtain vanishing asymptotic (transient) behaviour in the numerical solution, consistently with the properties of the analytical solution, without having to operate restrictions on the integration steplength

Investigation about the mechanisms involved in the onset of type 2 diabetes in absence of familiarity is the focus of a research project which has led to the development of a computational model that recapitulates the aetiology of the disease. The model simulates the metabolic and immunological alterations related to type-2 diabetes associated to several clinical, physiological and behavioural characteristics of representative virtual patients.

Invasive species cause huge amounts of environmental, economic, social and cultural damage in Europe and worldwide. Improving measures to control them is an ongoing challenge, and mathematical modeling and optimization are becoming increasingly popular as a tool to assist management (1; 2; 4). We analyse an optimal control model for the control of invasive species which aims to find the best temporal resource allocation strategy for the population reduction, under a budget constraint (3).

We obtain sharp decay estimates in time in the context of Sobolev spaces for smooth solutions to the one-dimensional Jin Xin model under the diffusion scaling, which are uniform with respect to the singular parameter of the scaling. This provides the convergence to the limit nonlinear parabolic equation both for large time and for the vanishing singular parameter. The analysis is performed by means of two main ingredients.

Mathematical models for subsoil decontamination by biological techniques