Background and limitations Impaired wound healing (WH) and chronic inflammation are hallmarks of non-communicable diseases (NCDs). However, despite WH being a recognized player in NCDs, mainstream therapies focus on (un)targeted damping of the inflammatory response, leaving WH largely unaddressed, owing to three main factors. The first is the complexity of the pathway that links inflammation and wound healing; the second is the dual nature, local and systemic, of WH; and the third is the limited acknowledgement of genetic and contingent causes that disrupt physiologic progression of WH.

MicroRNAs play a fundamental role in retinal development and function. To characterise the miRNome of the human retina, we carried out deep sequencing analysis on sixteen individuals. We established the catalogue of retina-expressed miRNAs, determined their relative abundance and found that a small number of miRNAs accounts for almost 90% of the retina miRNome. We discovered more than 3000 miRNA variants (isomiRs), encompassing a wide range of sequence variations, which include seed modifications that are predicted to have an impact on miRNA action.

In this paper, the asymptotic behaviour of the numerical solution to the Volterra integral equations is studied. In particular, a technique based on an appropriate splitting of the kernel is introduced, which allows one to obtain vanishing asymptotic (transient) behaviour in the numerical solution, consistently with the properties of the analytical solution, without having to operate restrictions on the integration steplength

In the present paper, we propose a numerical method for the simultaneous approximation of the finite Hilbert and Hadamard transforms of a given function f, supposing to know only the samples of f at equidistant points. As reference interval we consider [-1,1] and as approximation tool we use iterated Boolean sums of Bernstein polynomials, also known as generalized Bernstein polynomials. Pointwise estimates of the errors are proved, and some numerical tests are given to show the performance of the procedures and the theoretical results.

The recent COVID-19 pandemic came alongside with an "infodemic", with online social media flooded by often unreliable information associating the medical emergency with popular subjects of disinformation. In Italy, one of the first European countries suffering a rise in new cases and dealing with a total lockdown, controversial topics such as migrant flows and the 5G technology were often associated online with the origin and diffusion of the virus.

In a computer-aided system for skin cancer diagnosis, hair removal is one of the main challenges to face before applying a process of automatic skin lesion segmentation and classification. In this paper, we propose a straightforward method to detect and remove hair from dermoscopic images. Preliminarily, the regions to consider as candidate hair regions and the border/corner components located on the image frame are automatically detected. Then, the hair regions are determined using information regarding the saliency, shape and image colors.

A novel approach for extracting gauge-invariant information about spin-orbit coupling in gravitationally interacting binary systems is introduced. This approach is based on the "scattering holonomy", i.e. the integration (from the infinite past to the infinite future) of the differential spin evolution along the two worldlines of a binary system in hyperboliclike motion. We apply this approach to the computation, at the first post-Minkowskian approximation (i.e.

This study describes a semi-empirical model developed to estimate volumetric soil moisture (<mml:semantics>theta v</mml:semantics>) in bare soils during the dry season (March-May) using C-band (5.42 GHz) synthetic aperture radar (SAR) imagery acquired from the Sentinel-1 European satellite platform at a 20 m spatial resolution. The semi-empirical model was developed using backscatter coefficient (<mml:semantics>sigma degrees dB</mml:semantics>) and in situ soil moisture collected from Siruguppa taluk (sub-district) in the Karnataka state of India.