Background: DNA methylation is the main epigenetic mechanism driving changes in phenotype without altering genotype. Since the end of the seventies the role of methylation in cancer has become increasingly clear. Objective: The aim of this work is to shed light on the impact of methylation events on cancer cells, providing evidence that differential methylation in small regions, mostly characterized by hypermethylation, affects gene regulation while differential methylation in large genomic regions, mostly characterized by hypomethylation, affects chromosomal organization.

Internal waves describe the (linear) response of an incompressible sta- bly stratified fluid to small perturbations. The inclination of their group velocity with respect to the vertical is completely determined by their frequency. Therefore the reflection on a sloping boundary cannot follow Descartes' laws, and it is expected to be singular if the slope has the same inclination as the group velocity.

This paper describes a signal processing application an embedded hardware platform, based on Hilbert transform method for demodulation of digital signals.

Recent years have witnessed a massive push towards reproducible research in neuroscience. Unfortunately, this endeavor is often challenged by the large diversity of tools used, project-specific custom code and the difficulty to track all user-defined parameters. NeuroPycon is an open-source multi-modal brain data analysis toolkit which provides Python-based template pipelines for advanced multi-processing of MEG, EEG, functional and anatomical MRI data, with a focus on connectivity and graph theoretical analyses.