We present a simple model describing the chemical aggression undergone by calcium carbonate rocks in presence of acid atmosphere. A large literature is available on the deterioration processes of building stones, in particular in connection with problems concerning historical buildings in the field of Cultural Heritage. It is well known that the greatest aggression is caused by sulfur dioxide and nitrate. In this paper we consider the corrosion caused by sulphur dioxide, which, reacting with calcium carbonate, produces gypsum.

ZFP57 is required to maintain the germline-marked differential methylation at imprinting control regions (ICRs) in mouse embryonic stem cells (ESCs). Although DNA methylation has a key role in genomic imprinting, several imprinted genes are controlled by different mechanisms, and a comprehensive study of the relationship between DMR methylation and imprinted gene expression is lacking. To address the latter issue, we differentiated wild-type and Zfp57-/- hybrid mouse ESCs into neural precursor cells (NPCs) and evaluated allelic expression of imprinted genes.

The crack density within a fault's damage zone is thought to vary as seismic rupture is approached, as well as in the postseismic period. Moreover, external stress loads, seasonal or tidal, may also change the crack density in rocks, and all such processes can leave detectable signatures on seismic attenuation. Here we show that attenuation time histories from the San Andreas Fault at Parkfield are affected by seasonal loading cycles, as well as by 1.5-3-year periodic variations of creep rates, consistent with Turner et al.

Simulated data are crucial for evaluating epistasis detection tools in genome-wide association studies. Existing simulators are limited, as they do not account for linkage disequilibrium (LD), support limited interaction models of single nucleotide polymorphisms (SNPs) and only dichotomous phenotypes or depend on proprietary software.

The non-equilibrium structural and dynamical properties of semiflexible polymers confined to two dimensions under oscillatory shear flow are investigated by Brownian multi-particle collision dynamics. Two different scenarios will be considered: Filaments with both fixed ends [1] and wall-anchored chains [2].The results of the numerical studies will be presented and discussed. 1] A. Lamura, R. G. Winkler, 'Tethered semiflexible polymer under large amplitude oscillatory shear', Polymers 11, 737 (2019) [2] A. Lamura, R. G. Winkler, G.

Drug research, therapy development, and other areas of pharmacology and medicine can benefit from simula- tions and optimization of mathematical models that contain a mathematical description of interactions between systems elements at the cellular, tissue, organ, body, and population level. This approach is the foundation of systems medicine and precision medicine. Here, simulated experiments are performed with computers (in silico) first, and they are then replicated through lab experiments (in vivo or in vitro) or clinical studies.

We introduce a new methodology for anomaly detection (AD) in multichannel fast oscillating signals based on nonparametric penalized regression. Assuming the signals share similar shapes and characteristics, the estimation procedures are based on the use of the Rational-Dilation Wavelet Transform (RADWT), equipped with a tunable Q-factor able to provide sparse representations of functions with different oscillations persistence. Under the standard hypothesis of Gaussian additive noise, we model the signals by the RADWT and the anomalies as additive in each signal.

Background: Neutrophils are one of the key players in the human innate immune system (HIIS). In the event of an insult where the body is exposed to inflammation triggering moieties (ITMs), neutrophils are mobilized towards the site of insult and antagonize the inflammation. If the inflammation is cleared, neutrophils go into a programmed death called apoptosis.