We present a mechanistic model of drug release from a multiple emulsion into an external surrounding fluid. We consider a single multilayer droplet where the drug kinetics are described by a pure diffusive process through different liquid shells. The multilayer problem is described by a system of diffusion equations coupled via interlayer conditions imposing continuity of drug concentration and flux. Mass resistance is imposed at the outer boundary through the application of a surfactant at the external surface of the droplet.

The aim of this paper is to solve an inverse problem which regards a mass moving in a bounded domain. We assume that the mass moves following an unknown velocity field and that the evolution of the mass density can be described by a partial differential equation, which is also unknown. The input data of the problems are given by some snapshots of the mass distribution at certain times, while the sought output is the velocity field that drives the mass along its displacement.

Systems medicine (SM) has emerged as a powerful tool for studying the human body at the systems level with the aim of improving our understanding, prevention and treatment of complex diseases. Being able to automatically extract relevant features needed for a given task from high-dimensional, heterogeneous data, deep learning (DL) holds great promise in this endeavour. This review paper addresses the main developments of DL algorithms and a set of general topics where DL is decisive, namely, within the SM landscape.

We use Langevin dynamics simulations to study the mass diffusion problem across two adjacent porous layers of different transport properties. At the interface between the layers, we impose the Kedem-Katchalsky (KK) interfacial boundary condition that is well suited in a general situation. A detailed algorithm for the implementation of the KK interfacial condition in the Langevin dynamics framework is presented. As a case study, we consider a two-layer diffusion model of a drug-eluting stent.

Fluid flows hosting electrical phenomena are the subject of a fascinating and highly interdisciplinary scientific field. In recent years, the extraordinary success of electrospinning and solution-blowing technologies for the generation of polymer nanofibers has motivated vibrant research aiming at rationalizing the behavior of viscoelastic jets under applied electric fields or other stretching fields including gas streams.

The use of Euler polynomials and Euler numbers allows us to construct a quadrature rule similar to the well-known Euler--MacLaurin quadrature formula, using Euler (instead of Bernoulli) numbers, and even (instead of odd) order derivatives of a given function evaluated at the extrema of the considered interval. An expression of the remainder term and numerical examples are also given. © 2001, Heldermann Verlag. All rights reserved.

We prove an almost sure central limit theorem on the Poisson space, which is perfectly tailored for stabilizing functionals arising in stochastic geometry. As a consequence, we provide almost sure central limit theorems for (i) the total edge length of the k-nearest neighbors random graph. (ii) the clique count in random geometric graphs. and (iii) the volume of the set approximation via the Poisson-Voronoi tessellation.

We provide a framework to extend the relative entropy method to a class of diffusive relaxation systems with discrete velocities. The methodology is detailed in the toy case of the 1D Jin-Xin model under the diffusive scaling, and provides a direct proof of convergence to the limit parabolic equation in any interval of time, in the regime where the solutions are smooth. Recently, the same approach has been successfully used to show the strong convergence of a vector-BGK model to the 2D incompressible Navier-Stokes equations.