Simulated data are crucial for evaluating epistasis detection tools in genome-wide association studies. Existing simulators are limited, as they do not account for linkage disequilibrium (LD), support limited interaction models of single nucleotide polymorphisms (SNPs) and only dichotomous phenotypes or depend on proprietary software.

We revisit a method introduced by Tartar for proving global well-posedness of a semilinear hyperbolic system with null quadratic source in one space dimension. A remarkable point is that, since no dispersion effect is available for 1D hyperbolic systems, Tartar's approach is entirely based on spatial localization and finite speed of propagation.

The containment of the invasive species is a widespread problem in the environmental management, with a significant economic impact. We analyze an optimal control model which aims to find the best temporal resource allocation strategy for the removal of an invasive species. We derive the optimality system in the state and control variables and we use the phase-space analysis to provide qualitative insights about the behavior of the optimal solution.

A quadrature rule using Appell polynomials and generalizing both the Euler-MacLaurin quadrature formula and a similar quadrature rule, obtained in Bretti et al [15], which makes use of Euler (instead of Bernoulli) numbers and even (instead of odd) derivatives of the given function at the extrema of the considered interval, is derived. An expression of the remainder term and a numerical example are also enclosed.

No abstract available

The migration of endothelial cells (ECs) is critical for various processes including vascular wound healing, tumor angiogenesis, and the development of viable endovascular implants.

Bicontinuous interfacially jammed emulsion gels ("bijels") represent a new class of soft materials made of a densely packed monolayer of solid particles sequestered at the interface of a bicontinuous fluid. Their mechanical properties are relevant to many applications, such as catalysis, energy conversion, soft robotics, and scaffolds for tissue engineering. While their stationary bulk properties have been covered in depth, much less is known about their behavior in the presence of an external shear.

Introduction: Network and systems medicine has rapidly evolved over the past decade, thanks to computational and integrative tools, which stem in part from systems biology. However, major challenges and hurdles are still present regarding validation and translation into clinical application and decision making for precision medicine.

The paper deals with de la Vallee Poussin type interpolation on the square at tensor product Chebyshev zeros of the first kind. The approximation is studied in the space of locally continuous functions with possible algebraic singularities on the boundary, equipped with weighted uniform norms. In particular, simple necessary and sufficient conditions are proved for the uniform boundedness of the related Lebesgue constants. Error estimates in some Sobolev-type spaces are also given.

In this paper we revisit the problem of performing a QZ step with a so-called "perfect shift", which is an "exact" eigenvalue of a given regular pencil lambda B-A in unreduced Hessenberg-Triangular form. In exact arithmetic, the QZ step moves that eigenvalue to the bottom of the pencil, while the rest of the pencil is maintained in Hessenberg-Triangular form, which then yields a deflation of the given eigenvalue. But in finite-precision the QZ step gets "blurred" and precludes the deflation of the given eigenvalue.