In the past two decades, 7 coronaviruses have infected the human population, with two major outbreaks caused by SARS-CoV and MERS-CoV in the year 2002 and 2012, respectively. Currently, the entire world is facing a pandemic of another coronavirus, SARS-CoV-2, with a high fatality rate. The spike glycoprotein of SARS-CoV-2 mediates entry of virus into the host cell and is one of the most important antigenic determinants, making it a potential candidate for a vaccine. In this study, we have computationally designed a multi-epitope vaccine using spike glycoprotein of SARS-CoV-2.

The deep relationships, already existing since the 8th century BC, with Etruscan and Greek culture have triggered in the indigenous communities of Apulia and Basilicata a series of socio-cultural dynamics that will lead to a fundamental stage of social differentiation, based no longer on the role but on the high rank. If in the previous centuries the warrior was characterized only by the presence of the bronze spear, from the end of the 9th and especially in the 8th century the element that distinguishes it is the sword, which becomes a symbol of personal prestige.

t. The present work was inspired by the recent developments in laboratory experiments made on chip, where culturing of multiple cell species was possible.

The problem of inverse statistics (statistics of distances for which the signal fluctuations are larger than a certain threshold) in differentiable signals with power law spectrum, E(k) approximately k(-alpha), 3< or =alpha<5, is discussed. We show that for these signals, with random phases, exit-distance moments follow a bifractal distribution. We also investigate two dimensional turbulent flows in the direct cascade regime, which display a more complex behavior.

A full ODE model for the transmission of cholera is investigated, includ- ing both direct and indirect transmission and a nonlinear growth for pathogens. The direct problem is preliminarily studied and characterized in terms of reproduction number, endemic and disease free equilibria. The inverse problem is then discussed in view of parameter estimation and model identification via a Least Squares Approximation approach. The procedure is applied to real data coming from the recent Yemen cholera outbreak of 2017-2018.

Front propagation in two-dimensional steady and unsteady cellular flows is investigated in the limit of very fast reaction and sharp front, i.e., in the geometrical optics limit. For the steady flow, a simplified model allows for an analytical prediction of the front speed v(f) dependence on the stirring intensity U, which is in good agreement with numerical estimates. In particular, at large U, the behavior v(f)similar toU/log(U) is predicted. By adding small scales to the velocity field we found that their main effect is to renormalize the flow intensity.

The paper deals with de la Vallee Poussin type interpolation on the square at tensor product Chebyshev zeros of the first kind. The approximation is studied in the space of locally continuous functions with possible algebraic singularities on the boundary, equipped with weighted uniform norms. In particular, simple necessary and sufficient conditions are proved for the uniform boundedness of the related Lebesgue constants. Error estimates in some Sobolev-type spaces are also given.