Active fluids comprise a variety of systems composed of elements immersed in a fluid environment which can convert some form of energy into directed motion; as such they are intrinsically out-of-equilibrium in the absence of any external force. A fundamental problem in the physics of active matter concerns the understanding of how the characteristics of autonomous propulsion and agent-agent interactions determine the collective dynamics of the system.

Population genetics focuses on the analysis of genetic differences within and between-group of individuals and the inference of the populations' structure. These analyses are usually carried out using Bayesian clustering or maximum likelihood estimation algorithms that assign individuals to a given population depending on specific genetic patterns. Although several tools were developed to perform population genetics analysis, their standard graphical outputs may not be sufficiently informative for users lacking interactivity and complete information.

We investigate the rheology of strain-hardening spherical capsules, from the dilute to the concentrated regime under a confined shear flow using three-dimensional numerical simulations. We consider the effect of capillary number, volume fraction and membrane inextensibility on the particle deformation and on the effective suspension viscosity and normal stress differences of the suspension. The suspension displays a shear-thinning behaviour that is a characteristic of soft particles such as emulsion droplets, vesicles, strain-softening capsules and red blood cells.

Current theories of schizophrenia emphasize the role of altered information integration as the core dysfunction of this illness. While ample neuroimaging evidence for such accounts comes from investigations of spatial connectivity, understanding temporal disruptions is important to fully capture the essence of dysconnectivity in schizophrenia.

Visibility has an encompassing importance in humans' perception of the landscape, since the first encounter with a new environment normally occurs through sight. In historical and archaeological studies, two main methods (i.e., the geometric method and the Geographical Information System [GIS] computation) have been employed to determine the distance from which an object can be recognized. However, neither is exhaustive when applied to a maritime context, where the main factor affecting the visibility radius is weather.

We consider the generalization of discrete de la Vallée Poussin means on the square, obtained via tensor product by the univariate case. Pros and cons of such a kind of filtered approximation are discussed. In particular, under simple, we get near-best discrete approximation polynomials in the space of all locally continuous functions on the square with possible algebraic singularities on the boundary, equipped with the weighted uniform norm. In the four Chebychev cases, these polynomials also interpolate the function.

Background: Mutations of the mitochondrial protein paraplegin cause hereditary spastic paraplegia type 7 (SPG7), a so-far untreatable degenerative disease of the upper motoneuron with still undefined pathomechanism. The intermittent mitochondrial permeability transition pore (mPTP) opening, called flickering, is an essential process that operates to maintain mitochondrial homeostasis by reducing intra-matrix Ca and reactive oxygen species (ROS) concentration, and is critical for efficient synaptic function.

The computation of matrix functions using quadrature formulas and rational approximations of very large structured matrices using tensor trains (TT), and quantized tensor trains (QTT) is considered here. The focus is on matrices with a small TT/QTT rank. Some analysis of the error produced by the use of the TT/QTT representation and the underlying approximation formula used is also provided.

The T-box transcription factor TBX1 has critical roles in the cardiopharyngeal lineage and the gene is haploinsufficient in DiGeorge syndrome, a typical developmental anomaly of the pharyngeal apparatus. Despite almost two decades of research, if and how TBX1 function triggers chromatin remodeling is not known. Here, we explored genome-wide gene expression and chromatin remodeling in two independent cellular models of Tbx1 loss of function, mouse embryonic carcinoma cells P19Cl6, and mouse embryonic stem cells (mESCs).

Simulated data are crucial for evaluating epistasis detection tools in genome-wide association studies. Existing simulators are limited, as they do not account for linkage disequilibrium (LD), support limited interaction models of single nucleotide polymorphisms (SNPs) and only dichotomous phenotypes or depend on proprietary software.