Abstract not available

A full ODE model for the transmission of cholera is investigated, includ- ing both direct and indirect transmission and a nonlinear growth for pathogens. The direct problem is preliminarily studied and characterized in terms of reproduction number, endemic and disease free equilibria. The inverse problem is then discussed in view of parameter estimation and model identification via a Least Squares Approximation approach. The procedure is applied to real data coming from the recent Yemen cholera outbreak of 2017-2018.

The deep relationships, already existing since the 8th century BC, with Etruscan and Greek culture have triggered in the indigenous communities of Apulia and Basilicata a series of socio-cultural dynamics that will lead to a fundamental stage of social differentiation, based no longer on the role but on the high rank. If in the previous centuries the warrior was characterized only by the presence of the bronze spear, from the end of the 9th and especially in the 8th century the element that distinguishes it is the sword, which becomes a symbol of personal prestige.

In this paper we revisit the problem of performing a QZ step with a so-called "perfect shift", which is an "exact" eigenvalue of a given regular pencil lambda B-A in unreduced Hessenberg-Triangular form. In exact arithmetic, the QZ step moves that eigenvalue to the bottom of the pencil, while the rest of the pencil is maintained in Hessenberg-Triangular form, which then yields a deflation of the given eigenvalue. But in finite-precision the QZ step gets "blurred" and precludes the deflation of the given eigenvalue.

We introduce a new class of robust M-estimators for performing simultaneous parameter estimation and variable selection in high-dimensional regression models. We first explain the motivations for the key ingredient of our procedures which are inspired by regularization methods used in wavelet thresholding in noisy signal processing.

The feasibility of liver transplantation from old healthy donors suggests that this organ is able to preserve its functionality during aging. To explore the biological basis of this phenomenon, we characterized the epigenetic profile of liver biopsies collected from 45 healthy liver donors ranging from 13 to 90 years old using the Infinium HumanMethylation450 BeadChip. The analysis indicates that a large remodeling in DNA methylation patterns occurs, with 8823 age-associated differentially methylated CpG probes.

A notion of "2D well-balanced" for drift-diffusion is proposed. Exactness at steady-state, typical in 1D, is weakened by aliasing errors when deriving "truly 2D" numerical fluxes from local Green's function. A main ingredient for proving that such a property holds is the optimality of the trapezoidal rule for periodic functions. In accordance with practical evidence, a "Bessel scheme" previously introduced in [SIAM J. Numer. Anal. 56 (2018), pp. 2845-2870] is shown to be "2D well-balanced" (along with former algorithms known as "discrete weighted means" or "tailored schemes".