Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature.

The feasibility of liver transplantation from old healthy donors suggests that this organ is able to preserve its functionality during aging. To explore the biological basis of this phenomenon, we characterized the epigenetic profile of liver biopsies collected from 45 healthy liver donors ranging from 13 to 90 years old using the Infinium HumanMethylation450 BeadChip. The analysis indicates that a large remodeling in DNA methylation patterns occurs, with 8823 age-associated differentially methylated CpG probes.

Le ambre figurate in Italia meridionale tra VIII e V secolo a.C. Note sui centri di produzione e sulle botteghe

The study takes up some issues relating to the location of the workshops that produced the valuable figured ambers that marked the aristocratic burials of southern Italy from the eighth to fifth century BC. The contribution of findings and recent studies enabled us to assign some groups of artifacts to the activity of different workshops and even to identify outstanding artistic personalities, highlighting the undeniable stylistic connections between them.

Computing the eigenvectors of nonsymmetric tridiagonal matrices

The computation of the eigenvalue decomposition of matrices is one of the most investigated problems in numerical linear algebra. In particular, real nonsymmetric tridiagonal eigenvalue problems arise in a variety of applications. In this paper the problem of computing an eigenvector corresponding to a known eigenvalue of a real nonsymmetric tridiagonal matrix is considered, developing an algorithm that combines part of a QR sweep and part of a QL sweep, both with the shift equal to the known eigenvalue. The numerical tests show the reliability of the proposed method.