In the literature on Network Optimization, k-splittable flows were introduced to enhance modeling accuracy in cases where an upper bound on the number of supporting paths for each commodity needs to be imposed, thus extending the suitability of network flow tools for an increased number of practical applications. Such modeling feature has recently been extended to dynamic flows with the introduction of the novel strongly NP-hard Quickest Multicommodity k-splittable Flow Problem (QMCkFP).

Acute myeloid leukemia (AML) arises from a complex sequence of biological and finely orchestrated events that are still poorly understood. Increasingly, epigenetic studies are providing exciting findings that may be exploited in promising and personalized cutting-edge therapies. A more appropriate and broader screening of possible players in cancer could identify a master molecular mechanism in AML. Here, we build on our previously published study by evaluating a histone deacetylase (HDAC)2-mediated miRNA regulatory network in U937 leukemic cells.

To investigate the effects of Glatiramer Acetate (GA) on B cells by an integrated computational and experimental approach. GA is an immunomodulatory drug approved for the treatment of multiple sclerosis (MS). GA effect on B cells is yet to be fully elucidated. We compared transcriptional profiles of B cells from treatment-naive relapsing remitting MS patients, treated or not with GA for 6 hours in vitro, and of B cells before and after six months of GA administration in vivo.

Using standard cylindrical-like coordinates naturally adapted to the cylindrical symmetry of the Godel spacetime, we study elliptic like geodesic motion on hyperplanes orthogonal to the symmetry axis through an eccentricity-semi-latus rectum parametrization which is familiar from the Newtonian description of a two-body system. We compute several quantities which summarize the main features of the motion, namely the coordinate time and proper time periods of the radial motion, the frequency of the azimuthal motion, the full variation of the azimuthal angle over a period, and so on.

The energy content of cylindrical gravitational wave spacetimes is analyzed by considering two local descriptions of energy associated with the gravitational field, namely those based on the C-energy and the Bel-Robinson super-energy tensor. A Poynting-Robertson-like effect on the motion of massive test particles, beyond the geodesic approximation, is discussed, allowing them to interact with the background field through an external force which accounts for the exchange of energy and momentum between particles and waves.

The migration of endothelial cells (ECs) is critical for various processes including vascular wound healing, tumor angiogenesis, and the development of viable endovascular implants. EC migration is regulated by intracellular ATP; thus, elucidating the dynamics of intracellular ATP concentration is important.

We propose an approach to the numerical simulation of thin-film flows based on the lattice Boltzmann method. We outline the basic features of the method, show in which limits the expected thin-film equations are recovered, and perform validation tests. The numerical scheme is applied to the viscous Rayleigh-Taylor instability of a thin film and to the spreading of a sessile drop toward its equilibrium contact angle configuration. We show that the Cox-Voinov law is satisfied and that the effect of a tunable slip length on the substrate is correctly captured.

In transportation networks with limited capacities and travel times on the arcs, a class of problems attracting a growing scientific interest is represented by the optimal routing and scheduling of given amounts of flow to be transshipped from the origin points to the specific destinations in minimum time. Such problems are of particular concern to emergency transportation where evacuation plans seek to minimize the time evacuees need to clear the affected area and reach the safe zones.