MRI denoising by nonlocal means on multi-GPU

A critical issue in image restoration is noise removal, whose state-of-art algorithm, NonLocal Means, is highly demanding in terms of computational time. Aim of the present paper is to boost its performance by an efficient algorithm tailored to GPU hardware architectures. This algorithm adapts itself to several variants of the methodologies in terms of different strategies for estimating the involved filtering parameter, type of noise affecting data, multicomponent signals, spatial dimension of the images. Numerical experiments on brain Magnetic Resonance images are provided.

Lattice kinetic approach to non-equilibrium flows

We present a Lattice Boltzmann method for the simulation of a wide range of Knudsen regimes. The method is assessed in terms of normalised discharge for flow across parallel plates and three-dimensional flows in porous media. Available analytical solutions are well reproduced, supporting the the method as an appealing candidate to bridge the gap between the hydrodynamic regime and free molecular motion.

Nonequilibrium thermohydrodynamic effects on the Rayleigh-Taylor instability in compressible flows

The effects of compressibility on Rayleigh-Taylor instability (RTI) are investigated by inspecting the interplay between thermodynamic and hydrodynamic nonequilibrium phenomena (TNE, HNE, respectively) via a discrete Boltzmann model. Two effective approaches are presented, one tracking the evolution of the local TNE effects and the other focusing on the evolution of the mean temperature of the fluid, to track the complex interfaces separating the bubble and the spike regions of the flow.

A fluid dynamics multidimensional model of biofilm growth: stability, influence of environment and sensitivity

In this article, we study in detail the fluid dynamics system proposed in Clarelli et al. (2013, J. Math. Biol., 66, 1387-1408) to model the formation of cyanobacteria biofilms. After analysing the linear stability of the unique non-trivial equilibrium of the system, we introduce in the model the influence of light and temperature, which are two important factors for the development of a cyanobacteria biofilm.

On the dynamics of a generalized predator-prey system with Z-type control

We apply the Z-control approach to a generalized predator prey system and consider the specific case of indirect control of the prey population. We derive the associated Z-controlled model and investigate its properties from the point of view of the dynamical systems theory. The key role of the design parameter A. for the successful application of the method is stressed and related to specific dynamical properties of the Z-controlled model. Critical values of the design parameter are also found, delimiting the lambda-range for the effectiveness of the Z-method.

Looking for central tendencies in the conformational freedom of proteins using NMR measurements

We study the conformational freedom of a protein made by two rigid domains connected by a flexible linker. The conformational freedom is represented as an unknown probability distribution on the space of allowed states. A new algorithm for the calculation of the maximum allowable probability is proposed, which can be extended to any type of measurements. In this paper we use pseudo contact shifts and residual dipolar coupling. We reconstruct a single central tendency in the distribution and discuss in depth the results.

Rate equation leading to hype-type evolution curves: a mathematical approach in view of analysing technology development

The theoretical understanding of Gartner's "hype curve" is an interesting open question in deciding the strategic actions to adopt in presence of an incoming technology. In order to describe the hype behaviour quantitatively, we propose a mathematical approach based on a rate equation, similar to that used to describe quantum level transitions. The model is able to describe the hype curve evolution in many relevant conditions, which can be associated to various market parameters.

Mathematical model for transport of DNA plasmids from the external medium up to the nucleus by electroporation

We propose a mathematical model for the transport of DNA plasmids from the extracellular matrix up to the cell nucleus. The model couples two phenomena: the electroporation process, describing the cell membrane permeabilization to plasmids and the intracellular transport enhanced by the presence of microtubules. Numerical simulations of cells with arbitrary geometry, in 2D and 3D, and a network of microtubules show numerically the importance of the microtubules and the electroporation on the effectiveness of the DNA transfection, as observed by previous biological data.

Nullomers and high order nullomers in genomic sequences

A nullomer is an oligomer that does not occur as a subsequence in a given DNA sequence, i.e. it is an absent word of that sequence. The importance of nullomers in several applications, from drug discovery to forensic practice, is now debated in the literature. Here, we investigated the nature of nullomers, whether their absence in genomes has just a statistical explanation or it is a peculiar feature of genomic sequences. We introduced an extension of the notion of nullomer, namely high order nullomers, which are nullomers whose mutated sequences are still nullomers.