CTLs' repertoire shaping in the thymus: A Monte Carlo simulation

Motivation: The human immune system evolved a multi-layered control mechanism to eliminate self-reactive cells. Of these so-called tolerance induction mechanisms, lymphocytes T education in the thymus gland represents the very first one. This complicated process is not fully understood and quantitative models able to help in this endeavor are lacking.

Pulsed Thermography for Depth Profiling in Marble Sulfation

Deterioration of stones is a complex problem and one of the main concern for people working in the field of conservation and restoration of cultural heritage. One important point in cultural heritage is to obtain information about the damage in a non-invasive way. By this paper, we propose a new non-invasive tool that permits evaluation of the thickness of (Formula presented.) (gypsum) grown (sulfation) on marble stones, using a mathematical model on data detected by pulsed infrared thermography.

Towards a liquid self: How time, geography, and life experiences reshape the biological identity

The conceptualization of immunological self is amongst the most important theories of modern biology, representing a sort of theoretical guideline for experimental immunologists, in order to understand how host constituents are ignored by the immune system (IS). A consistent advancement in this field has been represented by the danger/damage theory and its subsequent refinements, which at present represents the most comprehensive conceptualization of immunological self. Here, we present the new hypothesis of "liquid self," which integrates and extends the danger/damage theory.

Text Lines and Words Variational Extraction from Ancient Printed Documents

In document image analysis the task of segmenting images of ancient printed documents in distinct elements is known to be a very complex problem. In general, these documents are of low quality and can present skew and degradations because of old printing or ink stains. To face these problems we will show and discuss the validity of the Mumford and Shah variational method, based on the ? convergence theory, along with its numerical handling.

Maps of PWV Temporal Changes by SAR Interferometry: A Study on the Properties of Atmosphere's Temperature Profiles

Recently, synthetic aperture radar interferometry (InSAR) has been recognized as a promising tool to generate high-resolution maps of atmospherical precipitable water vapor temporal changes (Delta PWV) from the propagation delay of radar signal in atmosphere. The relationship between Delta PWV and propagation delay mainly depends on the vertical profiles of temperature and water vapor pressure. In this letter, we present a methodology to study the spatial and temporal variations of the temperature's vertical profile and generate more accurate high-resolution Delta PWV maps by means of InSAR.

Intermittency in the relative separations of tracers and of heavy particles in turbulent flows

Results from direct numerical simulations (DNS) of particle relative dispersion in three-dimensional homogeneous and isotropic turbulence at Reynolds number Re?~300 are presented. We study point-like passive tracers and heavy particles, at Stokes number St=0.6,1 and 5. Particles are emitted from localised sources, in bunches of thousands, periodically in time, allowing an unprecedented statistical accuracy to be reached, with a total number of events for two-point observables of the order of 1011.

Heat-flux scaling in turbulent Rayleigh-Benard convection with an imposed longitudinal wind

We present a numerical study of Rayleigh-Benard convection disturbed by a longitudinal wind. Our results show that under the action of the wind, the vertical heat flux through the cell initially decreases, due to the mechanism of plume sweeping, and then increases again when turbulent forced convection dominates over the buoyancy. As a result, the Nusselt number is a nonmonotonic function of the shear Reynolds number. We provide simple models that capture with good accuracy all the dynamical regimes observed.

Linear-quadratic N-person and mean-field games: Infinite Horizon Games with Discounted Cost and Singular Limits

We consider stochastic differential games with N nearly identical players, linear-Gaussian dynamics, and infinite horizon discounted quadratic cost. Admissible controls are feedbacks for which the system is ergodic. We first study the existence of affine Nash equilibria by means of an associated system of N Hamilton-Jacobi-Bellman and N Kolmogorov-Fokker-Planck partial differential equations, proving that for small discount factors quadratic-Gaussian solutions exist and are unique.