Retinal gene therapy based on adeno-associated viral (AAV) vectors is safe and efficient in humans. The low intrinsic DNA transfer capacity of AAV has been expanded by dual vectors where a large expression cassette is split in two halves independently packaged in two AAV vectors. Dual AAV transduction efficiency, however, is greatly reduced compared to that obtained with a single vector. As AAV intracellular trafficking and processing are negatively affected by phosphorylation, this study set to identify kinase inhibitors that can increase dual AAV vector transduction.

Despite the development of new technologies in order to prevent the stealing of cars, the number of car thefts is sharply increasing. With the advent of electronics, new ways to steal cars were found. In order to avoid auto-theft attacks, in this paper we propose a machine learning based method to silently and continuously profile the driver by analyzing built-in vehicle sensors. We consider a dataset composed by 51 different features extracted by 10 different drivers, evaluating the efficiency of the proposed method in driver identification.

We propose a mathematical model to describe enzyme-based tissue degradation in cancer therapies. The proposed model combines the poroelastic theory of mixtures with the transport of enzymes or drugs in the extracellular space. The effect of the matrix-degrading enzymes on the tissue composition and its mechanical response are accounted for. Numerical simulations in 1D, 2D and axisymmetric (3D) configurations show how an injection of matrix-degrading enzymes alters the porosity of a biological tissue.

I fenomeni di trasporto, e la loro generalizzazione ai casi con reazione, costituiscono un capitolo molto importante della matematica applicata e trovano utilizzo in ambiti molto vari, che vanno dalla diffusione di sostanze inquinanti in atmosfera e in mare, ai processi industriali, alla biomatematica, alla propagazione di epidemie. Oltre alla loro rilevanza pratica, lo studio di tali fenomeni ha portato contributi molto importanti nella storia della fisica e della matematica.

We present a rigorous convergence result for smooth solutions to a singular semilinear hyperbolic approximation, called vector-BGK model, to the solutions to the incompressible Navier-Stokes equations in Sobolev spaces. Our proof deeply relies on the dissipative properties of the system and on the use of an energy which is provided by a symmetrizer, whose entries are weighted in a suitable way with respect to the singular perturbation parameter. This strategy allows us to perform uniform energy estimates and to prove the convergence by compactness.

In this paper, we consider a class of models describing multiphase fluids in the framework of mixture theory. The considered systems, in their more general form, contain both the gradient of a hydrostatic pressure, generated by an incompressibility constraint, and a compressible pressure depending on the volume fractions of some of the different phases. To approach these systems, we propose an approximation based on the Leray projection, which involves the use of a symbolic symmetrizer for quasi-linear hyperbolic systems and related paradifferential techniques.

We tackle the issue of measuring and understanding the visitors' dynamics in a crowded museum in order to create and calibrate a predictive mathematical model. The model is then used as a tool to manage, control and optimize the fruition of the museum. Our contribution comes with one successful use case, the Galleria Borghese in Rome, Italy.