We propose a novel in silico model for computing drug release from multi-layer capsules. The diffusion problem in such heterogeneous layer-by-layer composite medium is described by a system of coupled partial differential equations, which we solve analytically using separation of variables. In addition to the conventional partitioning and mass transfer interlayer conditions, we consider a surface finite mass transfer resistance, which corresponds to the case of a coated capsule.

In this study, we designed a novel drug-eluting coating for vascular implants consisting of a core coating of the anti-proliferative drug docetaxel ( DTX) and a shell coating of the platelet glycoprotein IIb/IIIa receptor monoclonal antibody SZ-21. The core/shell structure was sprayed onto the surface of 316L stainless steel stents using a coaxial electrospray process with the aim of creating a coating that exhibited a differential release of the two drugs. The prepared stents displayed a uniform coating consisting of nano/micro particles.

The topic of controlled drug release has received much attention in recent years, for example in the design of tablets and in local drug delivery devices such as stents, transdermal patches and orthopaedic implants. In recent years, we have developed a series of models for such devices to describe drug release from a polymeric platform and transport in surrounding biological tissues. These works have culminated in the development of a mathematical model that demonstrates agreement with in-vivo drug release and tissue uptake data, for the case of a drug-eluting stent.

We propose a novel in-silico model for computing drug release from multi-layer capsules. The diffusion problem in such heterogeneous layer-by-layer composite medium is described by a system of coupled partial differential equations, which we solve analytically using separation of variables. In addition to the conventional partitioning and mass transfer interlayer conditions, we consider also the case of finite mass transfer resistance, which corresponds to the case of a coated capsule.

Many drugs currently on the market or in development are poorly water-soluble. This presents a serious challenge to the pharmaceutical industry because orally delivered drugs that are poorly soluble tend to pass through the gastrointestinal tract before they can fully dissolve, leading to poor drug bioavailability. One strategy to improve drug solubility is to use a solid dispersion. A solid dispersion typically consists of a hydrophobic drug embedded in a hydrophilic polymer matrix.

The use of population dynamics models is essential to provide assessment of the fish abundance and advice on management and strategies for the fisheries. The stock-recruitment curve define the relationship between the spawning stock and the subsequent recruitment, describing nature's regulation of population size, whether or not the populations are being exploited. The two classical relations, established by Ricker and Shepherd, are: R (S) = b1S e-b2S , b1, b2 > 0 (4) R (S) = S b1 + b2Sb3 , b1, b2, b3 > 0 where S is the spawning stock and R is the recruitment, i.e.