We study the statistics of curvature and torsion of Lagrangian trajectories from direct numerical simulations of homogeneous and isotropic turbulence (at Re-lambda approximate to 280) in order to extract informations on the geometry of small-scale coherent structures in turbulent flows. We find that, as previously observed by Braun et al. (W. Braun, F. De Lillo, and B. Eckhardt, Geometry of particle paths in turbulent flows, J. Turbul. 7 (2006), p. 62) and Xu et al. (H. Xu, N.T. Ouellette, and E. Bodenschatz, Curvature of Lagrangian trajectories in turbulence, Phys. Rev. Lett. 98 (2007), p.

We present a boundary condition scheme for the lattice Boltzmann method that has significantly improved stability for modeling turbulent flows while maintaining excellent parallel scalability. Simulations of a three-dimensional lid-driven cavity flow are found to be stable up to the unprecedented Reynolds number Re = 5 x 10(4) for this setup. Excellent agreement with energy balance equations, computational and experimental results are shown. We quantify rises in the production of turbulence and turbulent drag, and determine peak locations of turbulent production.

Integral estimates for weak solutions to a class of Dirichlet problems for nonlinear, fully anisotropic, elliptic equations with a zero order term are obtained by symmetrization techniques. The anisotropy of the principal part of the operator is governed by a general n-dimensional Young function of the gradient which is not necessarily of polynomial type and need not satisfy the $\Delta_2$-condition.

Macrophages derived from monocyte precursors undergo specific polarization processes which are influenced by the local tissue environment: classically-activated (M1) macrophages, with a pro-inflammatory activity and a role of effector cells in Th1 cellular immune responses, and alternatively-activated (M2) macrophages, with anti-inflammatory functions and involved in immunosuppression and tissue repair. At least three different subsets of M2 macrophages, namely M2a, M2b and M2c, are characterized in the literature based on their eliciting signals.

Purpose: We studied microRNAs as potential biomarkers for Pompe disease. Methods: We analyzed microRNA expression by small RNA-seq in tissues from the disease murine model at two different ages (3 and 9 months), and in plasma from Pompe patients. Results: In the mouse model we found 211 microRNAs that were differentially expressed in gastrocnemii and 66 in heart, with a different pattern of expression at different ages. In a preliminary analysis in plasma from six patients 55 microRNAs were differentially expressed.

E-commerce is a sector in continual growth in all countries and, in particular, the increase in B2C (Business to Consumer) e-commerce market has important effects on last-mile deliveries in city areas. The delivery of a parcel to a consumer's address involves not only high costs for both couriers (extended car routes) and consumers (high prices) and also greater environmental pollution. The growing demand for deliveries in urban areas involves increases in traffic and congestion problems and, consequently, environmental issues.

Background & Aims: Acute liver failure is a rapidly progressive deterioration of hepatic function resulting in high mortality and morbidity. Metabolic enzymes can translocate to the nucleus to regulate histone acetylation and gene expression. Methods: Levels and activities of pyruvate dehydrogenase complex (PDHC) and lactate dehydrogenase (LDH) were evaluated in nuclear fractions of livers of mice exposed to various hepatotoxins including CD95-antibody, ?-amanitin, and acetaminophen.

During the seismic cycle, in nature and as well as in lab samples, the crack density of rocks varies substantially, as stressed rocks approach a critical state and eventually fail (Vasseur et al, 2017; Nur, 1972; Gupta, 1973) . At Earth scales, small periodical stress variations such as seasonal loading/unloading and tides (Johnson_etal_2017) are constantly being superimposed on the tectonic loading stress of crustal rocks, inducing periodic changes in crack porosity, pore-fluid pressure, and saturation, that should leave a signature on crustal attenuation.