An inversion method based on random sampling for real-time MEG neuroimaging

The MagnetoEncephaloGraphy (MEG) has gained great interest in neurorehabilitation training due to its high temporal resolution. The challenge is to localize the active regions of the brain in a fast and accurate way. In this paper we use an inversion method based on random spatial sampling to solve the real-time MEG inverse problem. Several numerical tests on synthetic but realistic data show that the method takes just a few hundredths of a second on a laptop to produce an accurate map of the electric activity inside the brain. Moreover, it requires very little memory storage.

Relativistic dissipation obeys Chapman-Enskog asymptotics: Analytical and numerical evidence as a basis for accurate kinetic simulations

We present an analytical derivation of the transport coefficients of a relativistic gas in (2 + 1) dimensions for both Chapman-Enskog (CE) asymptotics and Grad's expansion methods. We further develop a systematic calibration method, connecting the relaxation time of relativistic kinetic theory to the transport parameters of the associated dissipative hydrodynamic equations.

Designing a web Spatial Decision Support System based on Analytic Network Process to locate a freight lorry parking

The relevant role of freight lorry parking facilities as a tool to reduce nuisances and impact of economic activities in densely populated urban areas is widely recognised in the literature. Nevertheless, the literature currently lacks specific contributions addressing the use of a complex Multiple Criteria Decision Analysis (MCDA) approach for coping with an optimal location of freight lorry parking facilities in the urban context.

Sharp transitions in rotating turbulent convection: Lagrangian acceleration statistics reveal a second critical Rossby number

In Rayleigh-Bénard convection (RBC) for fluids with Prandtl number Pr1, rotation beyond a critical (small) rotation rate is known to cause a sudden enhancement of heat transfer, which can be explained by a change in the character of the boundary layer (BL) dynamics near the top and bottom plates of the convection cell. Namely, with increasing rotation rate, the BL signature suddenly changes from Prandtl-Blasius type to Ekman type.

Dynamic symmetry-breaking in mutually annihilating fluids with selective interfaces

The selective entrapment of mutually annihilating species within a phase-changing carrier fluid is explored by both analytical and numerical means. The model takes full account of the dynamic heterogeneity which arises as a result of the coupling between hydrodynamic transport, dynamic phase-transitions and chemical reactions between the participating species, in the presence of a selective droplet interface. Special attention is paid to the dynamic symmetry breaking between the mass of the two species entrapped within the expanding droplet as a function of time.

Discrete Eulerian model for population genetics and dynamics under flow

Marine species reproduce and compete while being advected by turbulent flows. It is largely unknown, both theoretically and experimentally, how population dynamics and genetics are changed by the presence of fluid flows. Discrete agent-based simulations in continuous space allow for accurate treatment of advection and number fluctuations, but can be computationally expensive for even modest organism densities. In this report, we propose an algorithm to overcome some of these challenges. We first provide a thorough validation of the algorithm in one and two dimensions without flow.

Hypoxia-regulated miRNAs in human mesenchymal stem cells: Exploring the regulatory effects in ischemic disorders

Human mesenchymal/stromal stem cells (hMSC) are the most promising cell source for adult cell therapies in regenerative medicine. Many clinical trials have reported the use of autologous transplantation of hMSCs in several disorders, but with limited results. To exert their potential, hMSCs could exhibit efficient homing and migration toward lesion sites among other effects, but the underlying process is not clear enough. To further increase the knowledge, we studied the co-regulation between hypoxia-regulated genes and miRNAs.

Critical nodes discovery in pathophysiological signaling pathways

Network-based ranking methods (e.g. centrality analysis) have found extensive use in systems medicine for the prediction of essential proteins, for the prioritization of drug targets candidates in the treatment of several pathologies and in biomarker discovery, and for human disease genes identification. Here we propose to use critical nodes as defined by the Critical Node Problem for the analysis of key physiological and pathophysiological signaling pathways, as target candidates for treatment and management of several cancer types, neurologic and inflammatory dysfunctions, among others.

New gravitational self-force analytical results for eccentric equatorial orbits around a Kerr black hole: Redshift invariant

The Detweiler-Barack-Sago redshift function for particles moving along slightly eccentric equatorial orbits around a Kerr black hole is currently known up to the second order in eccentricity, second order in spin parameter, and the 8.5 post-Newtonian order. We improve the analytical computation of such a gaugeinvariant quantity by including terms up to the fourth order in eccentricity at the same post-Newtonian approximation level.