The first carved ambers appear in the Adriatic area at the end of the eighth century BC with the beginning of the Orientalizing period. Among the most active centers, the Etruscan Verucchio is one of the main poles for the sorting of amber. At the beginning of the sixth century, a fundamental role is exercised from Piceno and the Etruscan Felsina, whose intercept part of the tra!cs previously directed on the Adriatic road.

One of the most formidable challenges in modern biology is to get a unified view of the various mechanisms governing the behavior and of the causal relationships among different parts of a living system. It is coming clearer nowadays that to get such comprehensive picture computational models embracing different observation levels in space and time have to be formulated to explain the enormous amount of data deriving from -omic high throughput measurements methods.