Detweiler's redshift invariant for extended bodies orbiting a Schwarzschild black hole

We compute the first-order self-force contribution to Detweiler's redshift invariant for extended bodies endowed with both dipolar and quadrupolar structure (with spin-induced quadrupole moment) moving along circular orbits on a Schwarzschild background. Our analysis includes effects which arc second order in spin, generalizing previous results for purely spinning particles. The perturbing body is assumed to move on the equatorial plane, the associated spin vector being orthogonal to it.

Evaluating visibility at sea: Instrumental data and historical nautical records. Mount Etna from the Calabrian Ionian coast (Italy)

Visibility has an encompassing importance in humans' perception of the landscape, since the first encounter with a new environment normally occurs through sight. In historical and archaeological studies, two main methods (i.e., the geometric method and the Geographical Information System [GIS] computation) have been employed to determine the distance from which an object can be recognized. However, neither is exhaustive when applied to a maritime context, where the main factor affecting the visibility radius is weather.

Non-local network dynamics via fractional graph Laplacians

We introduce non-local dynamics on directed networks through the construction of a fractional version of a non-symmetric Laplacian for weighted directed graphs. Furthermore, we provide an analytic treatment of fractional dynamics for both directed and undirected graphs, showing the possibility of exploring the network employing random walks with jumps of arbitrary length. We also provide some examples of the applicability of the proposed dynamics, including consensus over multi-agent systems described by directed networks.

Computing functions of very large matrices with small TT/QTT ranks by quadrature formulas

The computation of matrix functions using quadrature formulas and rational approximations of very large structured matrices using tensor trains (TT), and quantized tensor trains (QTT) is considered here. The focus is on matrices with a small TT/QTT rank. Some analysis of the error produced by the use of the TT/QTT representation and the underlying approximation formula used is also provided.

Unravelling the role of phoretic and hydrodynamic interactions in active colloidal suspensions

Active fluids comprise a variety of systems composed of elements immersed in a fluid environment which can convert some form of energy into directed motion; as such they are intrinsically out-of-equilibrium in the absence of any external force. A fundamental problem in the physics of active matter concerns the understanding of how the characteristics of autonomous propulsion and agent-agent interactions determine the collective dynamics of the system.

Synthetic Lethality Screening Identifies FDA-Approved Drugs That Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin

Tumor resistance to chemotherapy represents an important challenge in modern oncology. Although platinum (Pt)-based drugs have demonstrated excellent therapeutic potential, their effectiveness in a wide range of tumors is limited by the development of resistance mechanisms. One of these mechanisms includes increased cisplatin sequestration/efflux by the copper-transporting ATPase, ATP7B. However, targeting ATP7B to reduce Pt tolerance in tumors could represent a serious risk because suppression of ATP7B might compromise copper homeostasis, as happens in Wilson disease.

Structure and rheology of suspensions of spherical strain-hardening capsules

We investigate the rheology of strain-hardening spherical capsules, from the dilute to the concentrated regime under a confined shear flow using three-dimensional numerical simulations. We consider the effect of capillary number, volume fraction and membrane inextensibility on the particle deformation and on the effective suspension viscosity and normal stress differences of the suspension. The suspension displays a shear-thinning behaviour that is a characteristic of soft particles such as emulsion droplets, vesicles, strain-softening capsules and red blood cells.

Patient, interrupted: MEG oscillation dynamics reveal temporal dysconnectivity in schizophrenia

Current theories of schizophrenia emphasize the role of altered information integration as the core dysfunction of this illness. While ample neuroimaging evidence for such accounts comes from investigations of spatial connectivity, understanding temporal disruptions is important to fully capture the essence of dysconnectivity in schizophrenia.

NeuroPycon: An open-source python toolbox for fast multi-modal and reproducible brain connectivity pipelines

Recent years have witnessed a massive push towards reproducible research in neuroscience. Unfortunately, this endeavor is often challenged by the large diversity of tools used, project-specific custom code and the difficulty to track all user-defined parameters. NeuroPycon is an open-source multi-modal brain data analysis toolkit which provides Python-based template pipelines for advanced multi-processing of MEG, EEG, functional and anatomical MRI data, with a focus on connectivity and graph theoretical analyses.