Variational methods for image segmentation try to recover a piecewise smooth function together with a discontinuity set which represents the boundaries of the segmentation. This paper deals with a variational method that constrains the formation of discontinuities along smooth contours. The functional to be minimized, which involves the computation of the geometrical properties of the boundaries, is approximated by a sequence of functionals which can be discretized in a straightforward way. Computer examples of real images are presented to illustrate the feasibility of the method.

Endothelial cell (EC) migration is crucial for a wide range of processes including vascular wound healing, tumor angiogenesis, and the development of viable endovascular implants.

Controlled release of a drug contained in a spherical polymer capsule is of significant interest in many fields of medicine. There is growing interest in tailoring the erosion properties of the drug to help control and optimize the drug release process. Theoretical understanding of the nature of drug release from a bioerodible capsule is, therefore, important for designing effective drug delivery systems.

This paper deals with finite-difference approximations of Euler equations arising in the variational formulation of image segmentation problems. We illustrate how they can be defined by the following steps: (a) definition of the minimization problem for the Mumford-Shah functional (MSf), (b) definition of a sequence of functionals Gamma-convergent to the MSf, and (c) definition and numerical solution of the Euler equations associated to the k-th functional of the sequence.

We report the results of the regularization of the surface emissivity for the FORUM instrument.

We report new dynamical modes in confined soft granular flows, such as stochastic jetting and dripping, with no counterpart in continuum viscous fluids. The new modes emerge as a result of the propagation of the chaotic behavior of individual grains - here, monodisperse emulsion droplets - to the level of the entire system as the emulsion is focused into a narrow orifice by an external viscous flow. We observe avalanching dynamics and the formation of remarkably stable jets - single-file granular chains - which occasionally break, resulting in a non-Gaussian distribution of cluster sizes.

In this paper, the modal analysis model, made up by a linear combination of complex exponential functions, is considered. Padè approximants to the Z-transform of a noisy sample are then considered, and the asymptotic locus of their poles is studied. It turns out that this locus is strongly related to the complex exponentials of the model. By exploiting these properties, powerful methods for estimating the model parameters can be devised, which have both denoising and super-resolution capabilities.

Nonparametric univariate regression via wavelets is usually implemented under the assumptions of dyadic sample size, equally spaced fixed sample points, and i.i.d. normal errors. In this work, we propose, study and compare some wavelet based nonparametric estimation methods designed to recover a one-dimensional regression function for data that not necessary possess the above requirements. These methods use appropriate regularizations by penalizing the decomposition of the unknown regression function on a wavelet basis of functions evaluated on the sampling design.

The prediction of drug dissolution profiles is crucial for elucidating the pharmacokinetic behaviour of drugs and the bioavailability of dosage forms. In this work, we develop a mathematical model to describe the dissolution process of irregularly shaped particles. We use a complete dissolution model that accounts for both surface kinetics and convective diffusion. The mechanistic relationship between the mass transfer coefficient and the local curvature is derived from the fundamental physical laws governing these processes.

Drug delivery carriers are considered an encouraging approach for the localized treatment of disease with minimum effect on the surrounding tissue. Particularly, layer-by-layer releasing particles have gained increasing interest for their ability to develop multifunctional systems able to control the release of one or more therapeutical drugs and biomolecules. Although experimental methods can offer the opportunity to establish cause and effect relationships, the data collection can be excessively expensive or/and time-consuming.