Cardiac function in adolescents and young adults with 22q11.2 deletion syndrome without congenital heart disease

Background Diagnosis and treatment of 22q11.2 deletion syndrome (22q11.2DS) have led to improved life expectancy and achievement of adulthood. Limited data on long-term outcomes reported an increased risk of premature death for cardiovascular causes, even without congenital heart disease (CHD).

Bistable defect structures in blue phase devices

Blue phases are liquid crystals made up by networks of defects, or disclination lines. While existing phase diagrams show a striking variety of competing metastable topologies for these networks, very little is known as to how to kinetically reach a target structure, or how to switch from one to the other, which is of paramount importance for devices. We theoretically identify two confined blue phase I systems in which by applying an appropriate series of electric field it is possible to select one of two bistable defect patterns.

Switching and defect dynamics in multistable liquid crystal devices

We investigate the switching dynamics of multistable nematic liquid crystal devices. In particular, we identify a remarkably simple two-dimensional device which exploits hybrid alignment at the surfaces to yield a bistable response. We also consider a three-dimensional tristable nematic device with patterned anchoring, recently implemented in practice, and discuss how the director and disclination patterns change during switching.

Static and dynamic Melvin universes

We briefly review the known properties of Melvin's magnetic universe and study the propagation of test charged matter waves in this static spacetime. Moreover, the possible correspondence between the wave perturbations on the background Melvin universe and the motion of charged test particles is discussed. Next, we explore a simple scenario for turning Melvin's static universe into one that undergoes gravitational collapse. In the resulting dynamic gravitational field, the formation of cosmic double-jet configurations is emphasized.