A Stk4 -Foxp3-p65 transcriptional complex promotes Treg cell activation and homeostasis.

The molecular programs involved in regulatory T (Treg) cell activation and homeostasis remain incompletely understood. Here, we show that T cell receptor (TCR) signaling in Treg cells induces the nuclear translocation of serine/threonine kinase 4 (Stk4), leading to the formation of an Stk4-NF-?B p65-Foxp3 complex that regulates Foxp3- and p65-dependent transcriptional programs. This complex was stabilized by Stk4-dependent phosphorylation of Foxp3 on serine-418.

The dynamics of colloidal intrusions in liquid crystals: A simulation perspective

Dispersing colloidal particles into liquid crystals provides a promising avenue to build a novel class of materials, with potential applications, among others, as photonic crystals, biosensors, metamaterials and new generation liquid crystal devices. Understanding the physics and dynamical properties of such composite materials is then of high-technological relevance; it also provides a remarkable challenge from a fundamental science point of view due to the intricacies of the hydrodynamic equations governing their dynamical evolution.

Switching hydrodynamics in liquid crystal devices: A simulation perspective

In liquid crystal devices it is important to understand the physics underlying their switching between different states, which is usually achieved by applying or removing an electric field. Flow is known to be a key determinant of the timescales and pathways of the switching kinetics. Incorporating hydrodynamic effects into theories for liquid crystal devices is therefore important; however this is also highly non-trivial, and typically requires the use of accurate numerical methods.

Final MIPAS L1 and L2 V8 full mission reprocessing, lessons learnt and possible further improvements

MIPAS is a Fourier Transform spectrometer that measured the atmospheric limb emission spectra in the middle infrared on board the ENVISAT satellite. These measurements allowed the global monitoring of the three-dimensional (latitude, longitude and altitude) distribution of temperature and of the concentrations of many species, during both day and night, for 10 years, from July 2002 to April 2012. MIPAS measurements allowed to study the atmosphere from the upper troposphere to the stratosphere and above, up to the thermosphere.

Le diverse declinazioni della matematica per lo sviluppo dell'intelligenza artificiale nei seminari "AIM - Fundamentals and beyond".

Tra novembre 2020 e giugno 2021, l'Istituto per le Applicazioni del Calcolo "Mauro Picone" (IAC) ha realizzato un ciclo di seminari dedicati al rapporto tra Intelligenza Artificiale e Matematica, denominato AIM - Artificial Intelligence and Mathematics - Fundamentlas and beyond.

Degrado meccanico e chimico di materiali lapidei di importanza storico-ambientale

Progetto basato sullo sviluppo di modelli e metodi matematico-numerici per l'analisi di processi di degrado chimico (solfatazione, corrosione del ferro) e meccanico (danneggiamento, fratture). La finalità è di produrre gli strumenti per: a) simulare tali processi per poterli prevedere ed intervenire preventivamente, b)effettuare un monitoraggio a distanza, ovviamente non invasivo.

ENIGMA: modelling of Boulder Clay Glacier (Northern Foothills) and initiation of biological and biogeochemical studies of its glacial lakes

The Boulder Clay (BC) glacier and the surrounding area, partially covered by rock, ice and moraines, are considered by structure and morphology suitable to host a helicopter runway that would support the work efficiency of "Mario Zucchelli" Station and other international operational bases nearby. Actually the quasi-imperceptible slope of the bottom and the rocky containment walls make that area stable and easy to be converted.

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