Hydrodynamic and geometric effects in the sedimentation of model run-and-tumble microswimmers

The sedimentation process in an active suspension is the result of the competition between gravity and the autonomous motion of particles. We carry out simulations of run-and-tumble squirmers that move in a fluid medium, focusing on the dependence of the non-equilibrium steady state on the swimming properties.

An in-vivo validation of ESI methods with focal sources

Electrical source imaging (ESI) aims at reconstructing the electrical brain activity from measurements of the electric field on the scalp. Even though the localization of single focal sources should be relatively straightforward, different methods provide diverse solutions due to the different underlying assumptions. Furthermore, their input parameter(s) further affects the solution provided by each method, making localization even more challenging.

Loss-of-function variants in exon 4 of TAB2 cause a recognizable multisystem disorder with cardiovascular, facial, cutaneous, and musculoskeletal involvement

Purpose: This study aimed to describe a multisystemic disorder featuring cardiovascular, facial, musculoskeletal, and cutaneous anomalies caused by heterozygous loss-of-function variants in TAB2. Methods: Affected individuals were analyzed by next-generation technologies and genomic array. The presumed loss-of-function effect of identified variants was assessed by luciferase assay in cells transiently expressing TAB2 deleterious alleles. In available patients' fibroblasts, variant pathogenicity was further explored by immunoblot and osteoblast differentiation assays.

Single-Cell RNA Sequencing Analysis: A Step-by-Step Overview

Thanks to innovative sample-preparation and sequencing technologies, gene expression in individual cells can now be measured for thousands of cells in a single experiment. Since its introduction, single-cell RNA sequencing (scRNA-seq) approaches have revolutionized the genomics field as they created unprecedented opportunities for resolving cell heterogeneity by exploring gene expression profiles at a single-cell resolution. However, the rapidly evolving field of scRNA-seq invoked the emergence of various analytics approaches aimed to maximize the full potential of this novel strategy.

Altered brain criticality in Schizophrenia: New insights from MEG

Schizophrenia has a complex etiology and symptomatology that is difficult to untangle. After decades of research, important advancements towards a central biomarker are still lacking. One of the missing pieces is a better understanding of how non-linear neural dynamics are altered in this patient population. In this study, the resting-state neuromagnetic signals of schizophrenia patients and healthy controls were analyzed in the framework of criticality.

Ozone trend estimation using MIPAS ESA Level 2 Version 7 data

The largest part of the Earth's atmosphere ozone is located in the stratosphere, forming the so-called ozone layer. This layer played a key role in the development of life on Earth and still protects the planet from the most Dangerous ultraviolet radiation. After the discovery of the high ozone depletion potential of some anthropogenic origin substances (e.g. chlorofluorocarbons), some limitations in the production of the major ozone-depleting substances (ODS) have been applied with the Montreal Protocol in 1987.

Smoothed particle hydrodynamics method from a large eddy simulation perspective

The Smoothed Particle Hydrodynamics (SPH) method, often used for the modelling of the Navier- Stokes equations by a meshless Lagrangian approach, is revisited from the point of view of Large Eddy Simulation (LES). To this aim, the LES filtering procedure is recast in a Lagrangian framework by defining a filter that moves with the positions of the fluid particles at the filtered velocity.

Computing the Jordan structure of an eigenvalue

In this paper we revisit the problem of finding an orthogonal similarity transformation that puts an $n\times n$ matrix $A$ in a block upper-triangular form that reveals its Jordan structure at a particular eigenvalue $\lambda_0$. The obtained form in fact reveals the dimensions of the null spaces of $(A-\lambda_0 I)^i$ at that eigenvalue via the sizes of the leading diagonal blocks, and from this the Jordan structure at $\lambda_0$ is then easily recovered. The method starts from a Hessenberg form that already reveals several properties of the Jordan structure of $A$.

Mathematical tools for controlling invasive species in Protected Areas

A challenging task in the management of Protected Areas is the conservation of natural habitats and native endangered species through the optimization of control strategies for invasive plant or animal species, typically competing for the use of resources in a fragmented habitat [1]. We review two cases of control strategies on the wolf-wild boar populations in a Southern Italy Protected Area belonging to the Natura 2000 network [2,3].

Local membrane length conservation in two-dimensional vesicle simulation using a multicomponent lattice Boltzmann equation method

We present a method for applying a class of velocity-dependent forces within a multicomponent lattice Boltzmann equation simulation that is designed to recover continuum regime incompressible hydrodynamics. This method is applied to the problem, in two dimensions, of constraining to uniformity the tangential velocity of a vesicle membrane implemented within a recent multicomponent lattice Boltzmann simulation method, which avoids the use of Lagrangian boundary tracers.