To investigate the effects of Glatiramer Acetate (GA) on B cells by an integrated computational and experimental approach. GA is an immunomodulatory drug approved for the treatment of multiple sclerosis (MS). GA effect on B cells is yet to be fully elucidated. We compared transcriptional profiles of B cells from treatment-naive relapsing remitting MS patients, treated or not with GA for 6 hours in vitro, and of B cells before and after six months of GA administration in vivo.

The Detweiler-Barack-Sago redshift function for particles moving along slightly eccentric equatorial orbits around a Kerr black hole is currently known up to the second order in eccentricity, second order in spin parameter, and the 8.5 post-Newtonian order. We improve the analytical computation of such a gaugeinvariant quantity by including terms up to the fourth order in eccentricity at the same post-Newtonian approximation level.

The integral representation of some biological phenomena consists in Volterra equations whose kernels involve a convolution term plus a non convolution one. Some significative applications arise in linearised models of cell migration and collective motion, as described in Di Costanzo et al. (Discrete Contin. Dyn. Syst. Ser. B 25 (2020) 443-472), Etchegaray et al. (Integral Methods in Science and Engineering (2015)), Grec et al. (J. Theor. Biol. 452 (2018) 35-46) where the asymptotic behaviour of the analytical solution has been extensively investigated.

The energy content of cylindrical gravitational wave spacetimes is analyzed by considering two local descriptions of energy associated with the gravitational field, namely those based on the C-energy and the Bel-Robinson super-energy tensor. A Poynting-Robertson-like effect on the motion of massive test particles, beyond the geodesic approximation, is discussed, allowing them to interact with the background field through an external force which accounts for the exchange of energy and momentum between particles and waves.

Using standard cylindrical-like coordinates naturally adapted to the cylindrical symmetry of the Godel spacetime, we study elliptic like geodesic motion on hyperplanes orthogonal to the symmetry axis through an eccentricity-semi-latus rectum parametrization which is familiar from the Newtonian description of a two-body system. We compute several quantities which summarize the main features of the motion, namely the coordinate time and proper time periods of the radial motion, the frequency of the azimuthal motion, the full variation of the azimuthal angle over a period, and so on.

Acute myeloid leukemia (AML) arises from a complex sequence of biological and finely orchestrated events that are still poorly understood. Increasingly, epigenetic studies are providing exciting findings that may be exploited in promising and personalized cutting-edge therapies. A more appropriate and broader screening of possible players in cancer could identify a master molecular mechanism in AML. Here, we build on our previously published study by evaluating a histone deacetylase (HDAC)2-mediated miRNA regulatory network in U937 leukemic cells.

Molecular dynamics (MD) has become one of the most powerful tools of investigation in soft matter. Despite such success, simulations of large molecular environments are mostly run using the approximation of closed systems without the possibility of exchange of matter. Due to the molecular complexity of soft matter systems, an optimal simulation strategy would require the application of concurrent multiscale resolution approaches such that each part of a large system can be considered as an open subsystem at a high resolution embedded in a large coarser reservoir of energy and particles.

Two conflicting high-level goals govern the enforcement of security policies, abridged in the phrase ``high security at a low cost''. While these drivers seem irreconcilable, formal modelling languages and automated verification techniques can facilitate the task of finding the right balance. We propose a modelling language and a framework in which security checks can be relaxed or strengthened to save resources or increase protection, on the basis of trust relationships among communicating parties.

Drug releasing capsules and droplets are largely used in biomedical applications. Such vehicles consist of a drug-loaded core surrounded by a thin semi-permeable layer. Diffusion is by far the dominant mechanism in drug delivery, beside other physico-chemical factors, such as osmosis, drug dissolution, polymer swelling and degradation.

We consider the Erdös-Rényi random graph G(n,p) and we analyze the simple irreversible epidemic process on the graph, known in the literature as bootstrap percolation. We give a quantitative version of some results by Janson et al. (2012), providing a fine asymptotic analysis of the final size A_n of active nodes, under a suitable super-critical regime. More specifically, we establish large deviation principles for the sequence of random variables n-A_n/f (n) with explicit rate functions and allowing the scaling function f to vary in the widest possible range.