Nell'ambito del workshop d'inaugurazione dell'anno accademico dell'Associazione Matematica & Realta', la presentazione intende offrire alla platea degli insegnanti di matematica delle scuole superiori di secondo grado un esempio realmente implementato di attivita' di studio e ricerca di matematica applicata. Vi si trovano ben delineati i passi fondamentali che conducono dal problema reale alla soluzione numerica proposta, manifestando la necessita' di conoscenze interdisciplinari per giungere all' uso critico ed efficace dello strumento matematico.

We present the results of the algorithm modeling the horizontal gradients in the ESA retrieval of MIPAS data ORM v8.

A deep understanding of the dynamics and rheology of suspensions of vesicles, cells, and capsules is relevant for different applications, ranging from soft glasses to blood flow [1]. I will present the study of suspensions of fluid vesicles by a combination of molecular dynamics and mesoscale hydrodynamics simulations (multi-particle collision dynamics) in two dimensions [2], pointing out the big potential of the numerical method to address problems in soft matter.

Background: The DNA base composition is well known to be highly variable among organisms. Bio-physic studies on the effect of the GC increments on the DNA structure have shown that GC-richer DNA sequences are more bendable. The result was the keystone of the hypothesis proposing the metabolic rate as the major force driving the GC content variability, since an increased resistance to the torsion stress is mainly required during the transcription process to avoid DNA breakage.

The human retina is a specialized tissue involved in light stimulus transduction. Despite its unique biology, an accurate reference transcriptome is still missing. Here, we performed gene expression analysis (RNA-seq) of 50 retinal samples from non-visually impaired post-mortem donors. We identified novel transcripts with high confidence (Observed Transcriptome (ObsT)) and quantified the expression level of known transcripts (Reference Transcriptome (RefT)). The ObsT included 77 623 transcripts (23 960 genes) covering 137 Mb (35 Mb new transcribed genome).

International initiatives such as the Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) are collecting multiple datasets at different genome-scales with the aim of identifying novel cancer biomarkers and predicting survival of patients. To analyze such data, several statistical methods have been applied, among them Cox regression models. Although these models provide a good statistical framework to analyze omic data, there is still a lack of studies that illustrate advantages and drawbacks in integrating biological information and selecting groups of biomarkers.

Objectives Identifying the predictive factors of Sustained Virological Response (SVR) represents an important challenge in new interferon-based DAA therapies. Here, we analyzed the kinetics of antiviral response associated with a triple drug regimen, and the association between negative residual viral load at different time points during treatment. Methods Twenty-three HCV genotype 1 (GT 1a n = 11; GT1b n = 12) infected patients were included in the study.

This paper presents a comparative study between a large number of different existing sequential quadrature schemes suitable for Robust Design Optimization (RDO), with the inclusion of two partly original approaches. Efficiency of the different integration strategies is evaluated in terms of accuracy and computational effort: main goal of this paper is the identification of an integration strategy able to provide the integral value with a prescribed accuracy using a limited number of function samples.

A defect occurs on the inaccessible side of a metallic thin plate . We detect and evaluate from real thermal data collected.

We consider an initial-boundary value problem for a degenerate pseudoparabolic regularization of a nonlinear forward-backward-forward parabolic equation, with a bounded nonlinearity which is increasing at infinity. We prove existence of suitably defined nonnegative solutions of the problem in a space of Radon measures. Solutions satisfy several monotonicity and regularization properties; in particular, their singular part is nonincreasing and may disappear in finite time.