A two-layer model for drug delivery from a transdermal patch

A two-phasemathematical model describing the dynamics of a substance between two coupled media of different properties and dimensions is presented. A system of partial differential equations describes the diffusion and the binding/unbinding processes in both layers. Additional flux continuity at the interface and clearance conditions into systemic circulation are imposed. An eigenvalue problem with discontinuous coefficients is solved and an analytical solution is given in the form of an infinite series expansion.

Modelling the glycocalyx-endothelium-erythrocyte interaction in the microcirculation: a computational study

A novel, coarse-grained, single-framework 'Eulerian' model for blood flow in the microvascular circulation is presented and used to estimate the variations in flow properties that accrue from all of the following: (i) wall position variation, associated with the endothelial cells' (ECs) shape, (ii) glycocalyx layer (GL) effects and (iii) the particulate nature of blood. We stress that our new model is fully coupled and uses only a single Eulerian computational framework to recover complex effects, dispensing altogether with the need for, e.g. re-meshing and advected sets of Lagrangian points.

Near best discrete polynomial approximation via de la Vallee Poussin means

One of the most popular discrete approximating polynomials is the Lagrange interpolation polynomial and the Jacobi zeros provide a particularly convenient choice of the interpolation knots on [?1, 1]. However, it is well known that there is no point system such that the associate sequence of Lagrange polynomials, interpolating an arbitrary function f, would converge to f w.r.t. any weighted uniform or L1 norm.

Error bounds for Gauss-Jacobi quadrature rules

Gaussian quadrature has been extensively studied in literature and several error estimates have been proved under dierent smoothness assumptions of the integrand function. In this talk we are going to state a general error estimate for Gauss-Jacobi quadrature, based on the weighted moduli of smoothness introduced by Z. Ditzian and V. Totik in [1]. Such estimate improves a previous result in [1, Theorem 7.4.1] and it includes several error bounds from literature as particular cases.

Lattice Boltzmann Simulation of Mixed Convection Heat Transfer in a Driven Cavity with Non-uniform Heating of the Bottom Wall

The goal of this article is to study numerically the mixed convection in a differentially heated lid-driven cavity with non-uniform heating of the bottom wall. The velocity field is solved by a hybrid scheme with multiple relaxation time Lattice Boltzmann (MRT-LBM) model, while the temperature field is obtained by resolution of the energy balance equation using the finite difference method (FDM). First, the model is checked and validated using data from the literature. Validation of the present results with those available in the literature shows a good agreement.

Rayleigh-Bénard instability in graphene

Motivated by the observation that electrons in graphene, in the hydrodynamic regime of transport, can be treated as a two-dimensional ultrarelativistic gas with very low shear viscosity, we examine the existence of the Rayleigh-Bénard instability in a massless electron-hole plasma. First, we perform a linear stability analysis, derive the leading contributions to the relativistic Rayleigh number, and calculate the critical value above which the instability develops.

Sub-ms dynamics of the instability onset of electrospinning

Electrospun polymer jets are imaged for the first time at an ultra-high rate of 10 000 frames per second, investigating the process dynamics, and the instability propagation velocity and displacement in space. The polymer concentration, applied voltage bias and needle-collector distance are systematically varied, and their influence on the instability propagation velocity and on the jet angular fluctuations is analyzed. This allows us to unveil the instability formation and cycling behavior, and its exponential growth at the onset, exhibiting radial growth rates of the order of 10(3) s(-1).

Mathematical formulation of Bioventing Optimal Design Strategies

Bioventing is a technology used to abate the presence of pollutants in the subsoil. Microorganisms biodegrade the pollutant but the biochemical reaction requires oxygen and so an air ow is induced in the subsoil by means of injection and/or extraction wells. Costs, final result and decontamination time are reliant on contaminant type, soil permeability and several other factors, but oxygen subsoil concentration plays a very important role.

JETSPIN: A specific-purpose open-source software for simulations of nanofiber electrospinning

We present the open-source computer program JETSPIN, specifically designed to simulate the electro-spinning process of nanofibers. Its capabilities are shown with proper reference to the underlying model, as well as a description of the relevant input variables and associated test-case simulations. The various interactions included in the electrospinning model implemented in JETSPIN are discussed in detail. The code is designed to exploit different computational architectures, from single to parallel processor workstations.