We show that causality violation in a Kerr naked singularity spacetime is constrained by the existence of (radial) potential barriers. We extend to the class of vortical non-equatorial null geodesics confined to $$\theta $$? $$=$$= constant hyperboloids (boreal orbits) previous results concerning timelike ones (Calvani et al. in Gen Rel Gravit 9:155, 1978), showing that within this class of orbits, the causality principle is rigorously satisfied.

We investigate the effects of dissipative air drag on the dynamics of electrified jets in the initial stage of the electrospinning process. The main idea is to use a Brownian noise to model air drag effects on the uniaxial elongation of the jets. The developed numerical model is used to probe the dynamics of electrified polymer jets at different conditions of air drag force, showing that the dynamics of the charged jet is strongly biased by the presence of air drag forces. This study provides prospective beneficial implications for improving forthcoming electrospinning experiments.

In this paper we present a general model of drug release from a drug delivery device and the subsequent transport in biological tissue. The model incorporates drug diffusion, dissolution and solubility in the polymer coating, coupled with diffusion, convection and reaction in the biological tissue. Each layer contains bound and free drug phases so that the resulting model is a coupled two-phase two-layer system of partial differential equations. One of the novelties is the generality of the model in each layer.

A sharp integrability condition on the right-hand side of the p-Laplace system for all its solutions to be continuous is exhibited. Their uniform continuity is also analyzed and estimates for their modulus of continuity are provided. The relevant estimates are shown to be optimal as the right-hand side ranges in classes of rearrangement-invariant spaces, such as Lebesgue, Lorentz, Lorentz-Zygmund, and Marcinkiewicz spaces, as well as some customary Orlicz spaces.

A novel, coarse-grained, single-framework 'Eulerian' model for blood flow in the microvascular circulation is presented and used to estimate the variations in flow properties that accrue from all of the following: (i) wall position variation, associated with the endothelial cells' (ECs) shape, (ii) glycocalyx layer (GL) effects and (iii) the particulate nature of blood. We stress that our new model is fully coupled and uses only a single Eulerian computational framework to recover complex effects, dispensing altogether with the need for, e.g. re-meshing and advected sets of Lagrangian points.

In this paper we present a model of drug release from a drug eluting-stent and the subsequent drug transport in the arterial wall. In order to study the complete process, a two-phase mathematical model describing the transport of a drug between two coupled media of different properties and dimensions is presented. A system of partial differential equations describes both the solid-liquid transfer (dissolution) and diffusion processes in the polymeric substrate as well as diffusion, convection and reaction in the tissue layer.

We present the open-source computer program JETSPIN, specifically designed to simulate the electro-spinning process of nanofibers. Its capabilities are shown with proper reference to the underlying model, as well as a description of the relevant input variables and associated test-case simulations. The various interactions included in the electrospinning model implemented in JETSPIN are discussed in detail. The code is designed to exploit different computational architectures, from single to parallel processor workstations.

We obtain a comparison result for solutions to nonlinear fully anisotropic elliptic problems by means of anisotropic symmetrization. As consequence we deduce a priori estimates for norms of the relevant solutions.