Background: Direct-acting antiviral drugs (DAA) regimen improve the SVR rate. However, adverse effects often lead to therapy interruption.

Long-range NMR data, namely residual dipolar couplings (RDCs) from external alignment and paramagnetic data, are becoming increasingly popular for the characterization of conformational heterogeneity of multidomain biomacromolecules and protein complexes. The question addressed here is how much information is contained in these averaged data.

Recurrent focal neuropathy with liability to pressure palsies is a relatively frequent autosomal-dominant demyelinating neuropathy linked to peripheral myelin protein 22 (PMP22) gene deletions. The combination of PMP22 gene mutations with other genetic variants is known to cause a more severe phenotype than expected. We present the case of a patient with severe orthostatic hypotension since 12 years of age, who inherited a PMP22 gene deletion from his father. Genetic double trouble was suspected because of selective sympathetic autonomic disturbances.

Double integrals with algebraic and/or logarithmic singularities are of interest in the application of boundary element method, e.g. linear theory of the aerodynamics of slender bodies of revolution and in many other fields, for example computational electromagnetics. Therefore, the numerical evaluation of such type of integrals deserves attention.

MIPAS measurements on ENVISAT represent a unique database for the study of atmospheric composition and of the time variation of atmospheric constituents. For trend studies it is important that instrumental drifts are reduced.