Cardiovascular disease is the leading cause of mortality worldwide. Atherosclerosis, one of the most common forms of the disease, is characterized by a gradual formation of atherosclerotic plaque, hardening, and narrowing of the arteries. Nanomaterials can serve as powerful delivery platforms for atherosclerosis treatment. However, their therapeutic efficacy is substantially limited in vivo due to nonspecific clearance by the mononuclear phagocytic system.

The migration of endothelial cells (ECs) is critical for various processes including vascular wound healing, tumor angiogenesis, and the development of viable endovascular implants. EC migration is regulated by intracellular ATP and recent observations in our laboratory on ECs cultured on line patterns - surfaces where cellular adhesion is limited to 15 m-wide lines that physically confine the cells - have demonstrated very different migration behavior from cells on control unpatterned surfaces.

Dinur and Shamir's cube attack has attracted significant attention in the literature. Nevertheless, the lack of implementations achieving effective results casts doubts on its practical relevance. On the theoretical side, promising results have been recently achieved leveraging on division trails. The present paper follows a more practical approach and aims at giving new impetus to this line of research by means of a cipher-independent flexible framework that is able to carry out the cube attack on GPU/CPU clusters.

We explore the impact of geometrical corrugations on the near-wall flow properties of a soft material driven in a confined rough microchannel. By means of numerical simulations, we perform a quantitative analysis of the relation between the flow rate ? and the wall stress ?w for a number of setups, by changing both the roughness values as well as the roughness shape. Roughness suppresses the flow, with the existence of a characteristic value of ?w at which flow sets in. Just above the onset of flow, we quantitatively analyze the relation between ? and ?w.

In recent years, a number of functional inequalities have been derived for Poisson random measures, with a wide range of applications. In this paper, we prove that such inequalities can be extended to the setting of marked temporal point processes, under mild assumptions on their Papangelou conditional intensity. First, we derive a Poincare inequality. Second, we prove two transportation cost inequalities. The first one refers to functionals of marked point processes with a Papangelou conditional intensity and is new even in the setting of Poisson random measures.

To investigate the effects of Glatiramer Acetate (GA) on B cells by an integrated computational and experimental approach. GA is an immunomodulatory drug approved for the treatment of multiple sclerosis (MS). GA effect on B cells is yet to be fully elucidated. We compared transcriptional profiles of B cells from treatment-naive relapsing remitting MS patients, treated or not with GA for 6 hours in vitro, and of B cells before and after six months of GA administration in vivo.

This paper presents the results of an experiment aiming to measure the vibrational frequencies of the main structures of the medieval church of San Domenico (Matera, southern Italy) and relate them to the mechanical properties of geological stratigraphy and construction materials. Vibrational frequencies are measured by means of the ground-based radar inteferometry technique using a Ku-band radar. Time series of ground-based radar data are processed to measure displacements and vibration frequencies of the church structures.

The Wigner rotations arising from the combination of boosts along two different directions arc rederived from a relative boost point of view and applied to study gyroscope spin precession along timelike geodesics in a Kerr spacetime. First this helps to clarify the geometrical properties of Marck's recipe for reducing the equations of parallel transport along such world lines expressed in terms of the constants of the motion to a single differential equation for the essential planar rotation.