We present a method for applying a class of velocity-dependent forces within a multicomponent lattice Boltzmann equation simulation that is designed to recover continuum regime incompressible hydrodynamics. This method is applied to the problem, in two dimensions, of constraining to uniformity the tangential velocity of a vesicle membrane implemented within a recent multicomponent lattice Boltzmann simulation method, which avoids the use of Lagrangian boundary tracers.

Neural oscillations contribute to speech parsing via cortical tracking of hierarchical linguistic structures, including syllable rate. While the properties of neural entrainment have been largely probed with speech stimuli at either normal or artificially accelerated rates, the important case of natural fast speech has been largely overlooked. Using magnetoencephalography, we found that listening to naturally-produced speech was associated with cortico-acoustic coupling, both at normal (~6 syllables/s) and fast (~9 syllables/s) rates, with a corresponding shift in peak entrainment frequency.

The Smoothed Particle Hydrodynamics (SPH) method, often used for the modelling of the Navier- Stokes equations by a meshless Lagrangian approach, is revisited from the point of view of Large Eddy Simulation (LES). To this aim, the LES filtering procedure is recast in a Lagrangian framework by defining a filter that moves with the positions of the fluid particles at the filtered velocity.

Purpose: This study aimed to describe a multisystemic disorder featuring cardiovascular, facial, musculoskeletal, and cutaneous anomalies caused by heterozygous loss-of-function variants in TAB2. Methods: Affected individuals were analyzed by next-generation technologies and genomic array. The presumed loss-of-function effect of identified variants was assessed by luciferase assay in cells transiently expressing TAB2 deleterious alleles. In available patients' fibroblasts, variant pathogenicity was further explored by immunoblot and osteoblast differentiation assays.

In this paper we establish the boundedness and the higher differentiability of solutions to the {div(A(x,Du))+b(x)|u(x)|u(x)=fin ?u=0on ?? under a Sobolev assumption on the partial map x->A(x,?). The novelty here is that we deal with degenerate elliptic operator A(x,?) with p-growth, p>=2, with respect to the gradient variable, in presence of lower order terms. The interplay between b(x) and f(x), introduced in ([1]), gives a regularizing effect also in the degenerate elliptic setting.

Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2 5-phosphatase. Here we unveil a lysosomal response to the arrival of autophagosomal cargo in which OCRL plays a key part. We identify mitochondrial DNA and TLR9 as the cargo and the receptor that triggers and mediates, respectively, this response.

Thanks to innovative sample-preparation and sequencing technologies, gene expression in individual cells can now be measured for thousands of cells in a single experiment. Since its introduction, single-cell RNA sequencing (scRNA-seq) approaches have revolutionized the genomics field as they created unprecedented opportunities for resolving cell heterogeneity by exploring gene expression profiles at a single-cell resolution. However, the rapidly evolving field of scRNA-seq invoked the emergence of various analytics approaches aimed to maximize the full potential of this novel strategy.