Thanks to innovative sample-preparation and sequencing technologies, gene expression in individual cells can now be measured for thousands of cells in a single experiment. Since its introduction, single-cell RNA sequencing (scRNA-seq) approaches have revolutionized the genomics field as they created unprecedented opportunities for resolving cell heterogeneity by exploring gene expression profiles at a single-cell resolution. However, the rapidly evolving field of scRNA-seq invoked the emergence of various analytics approaches aimed to maximize the full potential of this novel strategy.

Atmospheric emissions of Carbon tetrachloride CCl4 are regulated by the Montreal Protocol due to its role as a strong ozone-depleting substance. The molecule has been the subject of recent increased interest as a consequence of the so called ``mystery of CCl4,'' the discrepancy between atmospheric observations and reported production and consumption. Surface measurements of CCl4 atmospheric concentrations have declined at a rate almost three times smaller than its lifetime-limited rate, suggesting persistent atmospheric emissions despite the ban.

Electrical source imaging (ESI) aims at reconstructing the electrical brain activity from measurements of the electric field on the scalp. Even though the localization of single focal sources should be relatively straightforward, different methods provide diverse solutions due to the different underlying assumptions. Furthermore, their input parameter(s) further affects the solution provided by each method, making localization even more challenging.

Switchable and adaptive substrates emerged as valuable tools for the control of wetting and actuation of droplet motion. Here we report a computational study of the dynamics of an unstable thin liquid film deposited on a switchable substrate, modelled with a space and time varying contact angle. With a static pattern, all the fluid is drained into droplets located around contact angle minima, whereas for a sufficiently large rate of wettability variation a state consisting of metastable rivulets is observed.

The Smoothed Particle Hydrodynamics (SPH) method, often used for the modelling of the Navier- Stokes equations by a meshless Lagrangian approach, is revisited from the point of view of Large Eddy Simulation (LES). To this aim, the LES filtering procedure is recast in a Lagrangian framework by defining a filter that moves with the positions of the fluid particles at the filtered velocity.

The aim of this paper is to deepen the application of value at risk in the cyber domain, with particular attention to its potential role in security investment valuation. Cyber risk is a fundamental component of the overall risk faced by any organization. In order to plan the size of security investments and to estimate the consequent risk reduction, managers strongly need to quantify it. Accordingly, they can decide about the possibility of sharing residual risk with a third party, such as an insurance company.

In this paper we establish the higher differentiability of solutions to the Dirichlet problem {div(A(x,Du))+b(x)u(x)=fin?u=0on??under a Sobolev assumption on the partial map x-> A(x, ?). The novelty here is that we take advantage from the regularizing effect of the lower order term to deal with bounded solutions.

Trends of soil organic carbon (SOC) are significant indicators for land and soil degradation. Decrease in SOC compromises the efforts to achieve by 2030, a land degradation neutral world, as required by Target 15.3 of the Seventeen Sustainable Development Goals (SDGs) adopted by United Nations in September 2015.

FORUM (Far-infrared Outgoing Radiation Understanding and Monitoring) will flight as the 9th ESA's Earth Explorer mission, and an End-to-End Simulator (E2ES) has been developed as a support tool for the mission selection process and the subsequent development phases. The current status of the FORUM E2ES project is presented, together with the characterization of the capabilities of a full physics retrieval code applied to FORUM data.