The first carved ambers appear in the Adriatic area at the end of the eighth century BC with the beginning of the Orientalizing period. Among the most active centers, the Etruscan Verucchio is one of the main poles for the sorting of amber. At the beginning of the sixth century, a fundamental role is exercised from Piceno and the Etruscan Felsina, whose intercept part of the tra!cs previously directed on the Adriatic road.

One of the most formidable challenges in modern biology is to get a unified view of the various mechanisms governing the behavior and of the causal relationships among different parts of a living system. It is coming clearer nowadays that to get such comprehensive picture computational models embracing different observation levels in space and time have to be formulated to explain the enormous amount of data deriving from -omic high throughput measurements methods.

A proposal for particles' initialization in PSO is presented and discussed, with focus on costly global unconstrained optimization problems. The standard PSO iteration is reformulated such that the trajectories of the particles are studied in an extended space, combining particles' position and speed. To the aim of exploring effectively and efficiently the optimization search space since the early iterations, the particles are initialized using sets of orthogonal vectors in the extended space (orthogonal initialization, ORTHOinit).

The role of protein Z (PZ) in the etiology of human disorders is unclear. A number of PZ gene variants, sporadic or polymorphic and found exclusively in the serine protease domain, have been observed. Crystal structures of PZ in complex with the PZ-dependent inhibitor (PZI) have been recently obtained. The aim of this study was a structural investigation of the serine protease PZ domain, aiming at finding common traits across disease-linked mutations. We performed 10-20 ns molecular dynamics for each of the observed PZ mutants to investigate their structure in aqueous solution.