The role of protein Z (PZ) in the etiology of human disorders is unclear. A number of PZ gene variants, sporadic or polymorphic and found exclusively in the serine protease domain, have been observed. Crystal structures of PZ in complex with the PZ-dependent inhibitor (PZI) have been recently obtained. The aim of this study was a structural investigation of the serine protease PZ domain, aiming at finding common traits across disease-linked mutations. We performed 10-20 ns molecular dynamics for each of the observed PZ mutants to investigate their structure in aqueous solution.

tProtected areas are experiencing increased levels of human pressure. To enable appropriate conserva-tion action, it is critical to map and monitor changes in the type and extent of land cover/use and habitatclasses, which can be related to human pressures over time. Satellite Earth observation (EO) data andtechniques offer the opportunity to detect such changes.

In this work the numerical simulations of a submarine in straight ahead motion with the appendages at several prescribed deflection angles are performed. Due to the complex geometry involved (the presence of moving appendages), these simulations are rather demanding form the point of view of both grid generation and accuracy of the numerical method. In order to analyze these aspects, the numerical solutions are computed by means of an unsteady Reynolds averaged Navier-Stokes equations solver, which is particularly effective because of the high order discretization schemes adopted.

The results of accurate compressible Navier-Stokes simulations of aerodynamic heating of the Vega launcher are presented. Three selected steady conditions of the Vega mission profile are considered: the first corresponding to the altitude of 18 km, the second to 25 km and the last to 33 km. The numerical code is based on the mathematical model described by the Favre-Average-Navier-Stokes equations; the turbulent model chosen for closure is the one-equation model by Spalart-Allmaras.

The first part of this work reviews the algebraic matricial approach to transport data inversion. It works for the convection-diffusion transport equation used for periodic signals and provides a formally exact solution, as well as a quantitative assessment of error bars. The standard methods of reconstruction infer the diffusivity D and pinch V by matching experimental data against those simulated by transport codes. These methods do not warrant the validity of either the underlying models of transport, or of the reconstructed D(r) and V(r), even when the results look reasonable.