In various cellular processes, bio-filaments like F-actin and F-tubulin are able to exploit chemical energy associated with polymerization to perform mechanicalwork against an obstacle loaded with an external force. The force-velocity relationship quantitatively summarizes the nature of this process. By a stochastic dynamical model, we give, together with the evolution of a staggered bundle of N-f rigid living filaments facing a loaded wall, the corresponding force-velocity relationship.

We address the problem of forecasting sales for fresh and highly perishable products, in the general context of supply chain management. The forecasting activity refers to the single item in a given store and started from a pre-processing phase for data analysis and normalization. Then data was used as input for a forecasting algorithm designed to be user interactive. We implemented three forecasting methods: ARIMA, ARIMAX and transfer function models. The exogenous components of the forecasting models took the impact of prices into account.

The time reversal invariance of classical dynamics is reconsidered in this paper with specific focus on its consequences for time correlation functions and associated properties such as transport coefficients. We show that, under fairly common assumptions on the interparticle potential, an isolated Hamiltonian system obeys more than one time reversal symmetry and that this entails non trivial consequences. Under an isotropic and homogeneous potential, in particular, eight valid time reversal operations exist.

Background: Macrophages cover a major role in the immune system, being the most plastic cell yielding several key immune functions. Methods: Here we derived a minimalistic gene regulatory network model for the differentiation of macrophages into the two phenotypes M1 (pro-) and M2 (anti-inflammatory).

Particle-laden turbulent flows occur in a variety of industrial applications as well as in naturally occurring flows. While the numerical simulation of such flows has seen significant advances in recent years, it still remains a challenging problem. Many studies investigated the rheology of dense suspensions in laminar flows as well as the dynamics of point-particles in turbulence.

The angle of directional change of tracer trajectories in rotating Rayleigh-Benard convection is studied as a function of the time increment tau between two instants of time along the trajectories, both experimentally and with direct numerical simulations. Our aim is to explore the geometrical characterization of flow structures in turbulent convection in a wide range of timescales and how it is affected by background rotation.

We use high-resolution direct numerical simulations to study the anisotropic contents of a turbulent, statistically homogeneous flow with random transitions among multiple energy containing states. We decompose the velocity correlation functions on different sectors of the three-dimensional group of rotations, SO(3), using a high-precision quadrature. Scaling properties of anisotropic components of longitudinal and transverse velocity fluctuations are accurately measured at changing Reynolds numbers.

Particle laden turbulent flows occur in a variety of industrial applications. While the numerical simulation of such flows has seen significant advances in recent years, it still remains a challenging problem. Many studies investigated the rheology of dense suspensions in laminar flows as well as the dynamics of point-particles in turbulence. Here we will present results on the development of numerical algorithms, based on the lattice Boltzmann method, suitable for the study of suspensions of finite-size particles under turbulent flow conditions.

Anisotropic particles are present in many natural and industrial flows. Here we perform direct numerical simulation (DNS) of turbulent pipe flows with dispersed finite-size prolate spheroids simulated by means of the lattice Boltzmann method (LBM). We consider three different particle shapes: spheroidal (aspect ratio 2 and 3) and spherical. These three simulations are complemented with a reference simulation of a single-phase flow. For the sake of comparison, all simulations, laden or unladen have the same energy input.