In this study, we designed a novel drug-eluting coating for vascular implants consisting of a core coating of the anti-proliferative drug docetaxel ( DTX) and a shell coating of the platelet glycoprotein IIb/IIIa receptor monoclonal antibody SZ-21. The core/shell structure was sprayed onto the surface of 316L stainless steel stents using a coaxial electrospray process with the aim of creating a coating that exhibited a differential release of the two drugs. The prepared stents displayed a uniform coating consisting of nano/micro particles.

We propose a novel in-silico model for computing drug release from multi-layer capsules. The diffusion problem in such heterogeneous layer-by-layer composite medium is described by a system of coupled partial differential equations, which we solve analytically using separation of variables. In addition to the conventional partitioning and mass transfer interlayer conditions, we consider also the case of finite mass transfer resistance, which corresponds to the case of a coated capsule.

The use of population dynamics models is essential to provide assessment of the fish abundance and advice on management and strategies for the fisheries. The stock-recruitment curve define the relationship between the spawning stock and the subsequent recruitment, describing nature's regulation of population size, whether or not the populations are being exploited. The two classical relations, established by Ricker and Shepherd, are: R (S) = b1S e-b2S , b1, b2 > 0 (4) R (S) = S b1 + b2Sb3 , b1, b2, b3 > 0 where S is the spawning stock and R is the recruitment, i.e.

Background. With the exponential increase in data dimension and methodological complexities, brain networks analysis with MEG and EEG has become an increasingly challenging and time-consuming endeavor. To date, performing all the data processing steps that are required for a complete MEG/EEG analysis pipeline often require the use of a multitude of software packages and in-house or custom tools (e.g. MRI segmentation, pre-processing, source reconstruction, graph theoretical analysis, statistics).

In order to understand the flow profiles of complex fluids, a crucial issue concerns the emergence of spatial correlations among plastic rearrangements exhibiting cooperativity flow behaviour at the macroscopic level. In this paper, the rate of plastic events in a Poiseuille flow is experimentally measured on a confined foam in a Hele-Shaw geometry. The correlation with independently measured velocity profiles is quantified by looking at the relationship between the localisation length of the velocity profiles and the localisation length of the spatial distribution of plastic events.