Background: Major Depressive Disorder (MDD) is a psychiatric illness that is often associated with potentially life -threatening physiological changes and increased risk for suicidal behavior. Electroencephalography (EEG) research suggests an association between depression and specific frequency imbalances in the frontal brain re-gion.

In this paper we analyze the stability of the problem of performing a rational QZ$step with a shift that is an eigenvalue of a given regular pencil H-lambda K in unreduced Hessenberg-Hessenberg form. In exact arithmetic, the backward rational QZ step moves the eigenvalue to the top of the pencil, while the rest of the pencil is maintained in Hessenberg-Hessenberg form, which then yields a deflation of the given shift. But in finite-precision the rational QZ step gets ``blurred'' and precludes the deflation of the given shift at the top of the pencil.

In this manuscript we propose a numerical method for non-linear integro-differential systems arising in age-of-infection models in a heterogeneously mixed population. The discrete scheme is based on direct quadrature methods and provides an unconditionally positive and bounded solution. Furthermore, we prove the existence of the numerical final size of the epidemic and show that it tends to its continuous equivalent as the discretization steplength vanishes.

In this paper we consider a non-standard discretization to a Volterra integro-dierential system which includes a number of age-of-infection models in the literature. The aim is to provide a general framework to analyze the proposed scheme for the numerical solution of a class of problems whose continuous dynamic is well known in the literature and allow a deeper analysis in cases where the theory lacks

We present and release in open source format a sparse linear solver which efficiently exploits heterogeneous parallel computers. The solver can be easily integrated into scientific applications that need to solve large and sparse linear systems on modern parallel computers made of hybrid nodes hosting Nvidia Graphics Processing Unit (GPU) accelerators.

Summary: We present RNASeqGUI R package, a graphical user interface (GUI) for the identification of differentially expressed genes across multiple biological conditions. This R package includes some wellk-nown RNA-Seq tools, available at www.bioconductor.org. RNASeqGUI package is not just a collection of some known methods and functions, but it is designed to guide the user during the entire analysis process. RNASeqGUI package is mainly addressed to those users who have little experience with command-line software.