This contribution outlines current research aimed at developing models for personalized type 2 diabetes mellitus (T2D) prevention in the framework of the European project PRAESIIDIUM (Physics Informed Machine Learn-ing-Based Prediction and Reversion of Impaired Fasting Glucose Management) aimed at building a digital twin for preventing T2D in patients at risk.

This paper considers a Multiple Objective variant of the Critical Disruption Path problem to extend its suitability in a range of security operations relying on path-based network interdiction, including flight pattern optimisation for surveillance.

In this work, we propose and explore a novel network-constraint survival methodology considering the Weibull accelerated failure time (AFT) model combined with a penalized likelihood approach for variable selection and estimation [2]. Our estimator explicitly incorporates the correlation patterns among predictors using a double penalty that promotes both sparsity and the grouping effect. In or- der to solve the structured sparse regression problems we present an efficient iterative computational algorithm based on proximal gradient descent method [1].

In recent years there has been a growing interest in frame based de-noising procedures. The advantage of frames with respect to classical orthonor- mal bases (e.g. wavelet, Fourier, polynomial) is that they can furnish an efficient representation of a more broad class of signals. For example, signals which have fast oscillating behavior as sonar, radar, EEG, stock market, audio and speech are much more well represented by a frame (with similar oscillating characteristic) than by a classical wavelet basis, although the frame representation for such kind of signals can be not properly sparse.

Epigenetic modifications are correlated to environmental factors. Exposure to ambient air pollution may contribute to the development of different diseases such as cancer, cardiovascular diseases, and neurological and metabolic disorders. Looking for the association between DNA methylation and exposure biomarkers may help in the prevention of adverse effects. Association analysis can be carried out through regression modeling.

In this paper, we aim at developing new methods to join machine learning techniques and macroscopic differential models for vehicular traffic estimation and forecast. It is well known that data-driven and model- driven approaches have (sometimes complementary) advantages and drawbacks. We consider here a dataset with flux and velocity data of vehicles moving on a highway, collected by fixed sensors and classified by lane and by class of vehicle.

In this paper, we study fluctuations and precise deviations of cumulative INAR time series, both in a non-stationary and in a stationary regime. The theoretical results are based on the recent mod- convergence theory as presented in Féray et al., 2016. We apply our findings to the construction of approximate confidence intervals for model parameters and to quantile calculation in a risk management context.

We study the consistency and the oracle properties of the adaptive Lasso estimator for the coefficients of a linear AR(p) time series with a strictly stationary white noise (not necessarily described by i.i.d. r.v.'s). We apply the results to INAR(p) time series and to the non-parametric inference of the fertility function of a Hawkes point process. We present some numerical simulations to emphasize the advantages of the proposed procedure with respect to more classical ones and finally we apply it to a set of epidemiological data