Hydrodynamic singular regimes in 1+1 kinetic models and spectral numerical methods
Classical results from spectral theory of stationary linear kinetic equations are applied to efficiently approximate two physically relevant weakly nonlinear kinetic models: a model of chemotaxis involving a biased velocity-redistribution integral term, and a Vlasov-Fokker-Planck (VFP) system. Both are coupled to an attractive elliptic equation producing corresponding mean-field potentials.
Distinct Antigen Delivery Systems Induce Dendritic Cells' Divergent Transcriptional Response: New Insights from a Comparative and Reproducible Computational Analysis.
Vaccination is the most successful and cost-effective method to prevent infectious diseases. However, many vaccine antigens have poor in vivo immunogenic potential and need adjuvants to enhance immune response. The application of systems biology to immunity and vaccinology has yielded crucial insights about how vaccines and adjuvants work. We have previously characterized two safe and powerful delivery systems derived from non-pathogenic prokaryotic organisms: E2 and fd filamentous bacteriophage systems.
A discrete in continuous mathematical model of cardiac progenitor cells formation and growth as spheroid clusters (cardiospheres)
We propose a discrete in continuous mathematical model describing the in vitro growth process of biophsy-derived mammalian cardiac progenitor cells growing as clusters in the form of spheres (Cardiospheres). The approach is hybrid: discrete at cellular scale and continuous at molecular level. In the present model cells are subject to the self-organizing collective dynamics mechanism and, additionally, they can proliferate and differentiate, also depending on stochastic processes. The two latter processes are triggered and regulated by chemical signals present in the environment.
Stability and boundedness of numerical approximations to Volterra integral equations
Volterra Integral Equations (VIEs) arise in many problems of real life, as, for example, feedback control theory, population dynamics and fluid dynamics. A reliable numerical simulation of these phenomena requires a careful analysis of the long time behavior of the numerical solution. Here we develop a numerical stability theory for Direct Quadrature (DQ) methods which applies to a quite general and representative class of problems. We obtain stability results under some conditions on the stepsize and, in particular cases, unconditional stability for DQ methods of whatever order.
Relativistic Tidal Acceleration of Astrophysical Jets
Within the framework of general relativity, we investigate the tidal acceleration of astrophysical jets relative to the central collapsed configuration ("Kerr source"). To simplify matters, we neglect electromagnetic forces throughout; however, these must be included in a complete analysis. The rest frame of the Kerr source is locally defined via the set of hypothetical static observers in the spacetime exterior to the source.
Comparison results for nonlinear anisotropic parabolic problems
Comparison results for solutions to the Dirichlet problems for a class of nonlinear, anisotropic parabolic equations are established. These results are obtained through a semidiscretization method in time after providing estimates for solutions to anisotropic elliptic problems with zero-order terms.