A new technique for nonparametric regression of multichannel signals is presented. The technique is based on the use of the Rational-Dilation Wavelet Transform (RADWT), equipped with a tunable Q-factor able to provide sparse representations of functions with different oscillations persistence. In particular, two different frames are obtained by two RADWT with different Q-factors that give sparse representations of functions with low and high resonance.

Background and limitations Impaired wound healing (WH) and chronic inflammation are hallmarks of non-communicable diseases (NCDs). However, despite WH being a recognized player in NCDs, mainstream therapies focus on (un)targeted damping of the inflammatory response, leaving WH largely unaddressed, owing to three main factors. The first is the complexity of the pathway that links inflammation and wound healing; the second is the dual nature, local and systemic, of WH; and the third is the limited acknowledgement of genetic and contingent causes that disrupt physiologic progression of WH.

Background: Neutrophils are one of the key players in the human innate immune system (HIIS). In the event of an insult where the body is exposed to inflammation triggering moieties (ITMs), neutrophils are mobilized towards the site of insult and antagonize the inflammation. If the inflammation is cleared, neutrophils go into a programmed death called apoptosis.

The recent COVID-19 pandemic came alongside with an "infodemic", with online social media flooded by often unreliable information associating the medical emergency with popular subjects of disinformation. In Italy, one of the first European countries suffering a rise in new cases and dealing with a total lockdown, controversial topics such as migrant flows and the 5G technology were often associated online with the origin and diffusion of the virus.

In this paper, the asymptotic behaviour of the numerical solution to the Volterra integral equations is studied. In particular, a technique based on an appropriate splitting of the kernel is introduced, which allows one to obtain vanishing asymptotic (transient) behaviour in the numerical solution, consistently with the properties of the analytical solution, without having to operate restrictions on the integration steplength

MicroRNAs play a fundamental role in retinal development and function. To characterise the miRNome of the human retina, we carried out deep sequencing analysis on sixteen individuals. We established the catalogue of retina-expressed miRNAs, determined their relative abundance and found that a small number of miRNAs accounts for almost 90% of the retina miRNome. We discovered more than 3000 miRNA variants (isomiRs), encompassing a wide range of sequence variations, which include seed modifications that are predicted to have an impact on miRNA action.

Phosphoinositides (PtdIns) control fundamental cell processes, and inherited defects of PtdIns kinases or phosphatases cause severe human diseases, including Lowe syndrome due to mutations in OCRL, which encodes a PtdIns(4,5)P2 5-phosphatase. Here we unveil a lysosomal response to the arrival of autophagosomal cargo in which OCRL plays a key part. We identify mitochondrial DNA and TLR9 as the cargo and the receptor that triggers and mediates, respectively, this response.

Despite numerous important contributions, the investigation of brain connectivity with magnetoencephalography (MEG) still faces multiple challenges. One critical aspect of source-level connectivity, largely overlooked in the literature, is the putative effect of the choice of the inverse method on the subsequent cortico-cortical coupling analysis. We set out to investigate the impact of three inverse methods on source coherence detection using simulated MEG data. To this end, thousands of randomly located pairs of sources were created.

The crack density within a fault's damage zone is thought to vary as seismic rupture is approached, as well as in the postseismic period. Moreover, external stress loads, seasonal or tidal, may also change the crack density in rocks, and all such processes can leave detectable signatures on seismic attenuation. Here we show that attenuation time histories from the San Andreas Fault at Parkfield are affected by seasonal loading cycles, as well as by 1.5-3-year periodic variations of creep rates, consistent with Turner et al.

The non-equilibrium structural and dynamical properties of semiflexible polymers confined to two dimensions under oscillatory shear flow are investigated by Brownian multi-particle collision dynamics. Two different scenarios will be considered: Filaments with both fixed ends [1] and wall-anchored chains [2]. The results of the numerical studies will be presented and discussed. References [1] A. Lamura, R. G. Winkler Polymers 2019, 11, 737. DOI:10.3390/polym11040737 [2] A. Lamura, R. G. Winkler, G. Gompper pre-print 2021