Effective treatment of glioma and other central nervous system (CNS) diseases is hindered by the presence of the blood-brain barrier (BBB). A novel nano-delivery vehicle system composed of PLGA-lysoGM1/DOX micelles was developed to cross the BBB for CNS treatment. We have shown that doxorubicin (DOX) as a model drug encapsulated in PLGA-lysoGM1 micelles can achieve up to 3.8% loading efficiency and 61.6% encapsulation efficiency by the orthogonal test design.

In this paper we provide emission estimates due to vehicular traffic via Generic Second Order Models. We generalize them to model road networks with merge and diverge junctions. The procedure consists on solving the Riemann Problem at junction assuming the maximization of the flow and a priority rule for the incoming roads. We provide some numerical results for a single-lane roundabout and we propose an application of the given procedure to estimate the production of nitrogen oxides (NOx) emission rates.

We use computer simulations to study the morphology and rheological properties of a bidimensional emulsion resulting from a mixture of a passive isotropic fluid and an active contractile polar gel, in the presence of a surfactant that favours the emulsification of the two phases. By varying the intensity of the contractile activity and of an externally imposed shear flow, we find three possible morphologies. For low shear rates, a simple lamellar state is obtained.

t. The present work was inspired by the recent developments in laboratory experiments made on chip, where culturing of multiple cell species was possible.

SUNBIM (Supramolecular and sUbmolecular Nano- and Biomaterials X-ray IMaging) is a computer suite of integrated programs which, through a user-friendly graphical interface, is able to perform a number of functions for (GI)SAXS-(GI)WAXS data analysis [1] such as: centering, q-scale calibration, two-dimensional to one-dimensional folding of small- and wide-angle X-ray scattering (SAXS/WAXS) data, also in grazing-incidence (GISAXS/GIWAXS); indexing of two-dimensional GISAXS frames and extraction of one-dimensional GISAXS profiles along specific cuts; quantitative scanning microscopy in absorption

Thisarticleisconcernedwiththeasymptoticbehaviorofthetwo-dimensionalinviscid Boussinesq equations with a damping term in the velocity equation. Precisely, we provide the time- decay rates of the smooth solutions to that system. The key ingredient is a careful analysis of the Green kernel of the linearized problem in Fourier space, combined with bilinear estimates and interpolation inequalities for handling the nonlinearity.

We present a mechanistic model of drug release from a multiple emulsion into an external surrounding fluid. We consider a single multilayer droplet where the drug kinetics are described by a pure diffusive process through different liquid shells. The multilayer problem is described by a system of diffusion equations coupled via interlayer conditions imposing continuity of drug concentration and flux. Mass resistance is imposed at the outer boundary through the application of a surfactant at the external surface of the droplet.

We numerically investigate the rheological response of a noncoalescing multiple emulsion under a symmetric shear flow. We find that the dynamics significantly depends on the magnitude of the shear rate and on the number of the encapsulated droplets, two key parameters whose control is fundamental to accurately select the resulting nonequiibrium steady states.